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| 智能水凝胶在组织工程中的应用 | |
| 引用本文： | 张丁文,刘燕飞,亓 鹏,刘建国. 智能水凝胶在组织工程中的应用[J]. 中国组织工程研究, 2014, 18(12): 1944-1950. DOI: 10.3969/j.issn.2095-4344.2014.12.023 |
| 作者姓名： | 张丁文 刘燕飞 亓 鹏 刘建国 |
| 作者单位： | 1遵义医学院口腔学院，贵州省遵义市 5630002贵州省细胞工程重点实验室，贵州省遵义市 5630003贵州省高等学校口腔疾病研究特色重点实验室，贵州省遵义市 563000 |
| 基金项目： | 贵州省优秀青年科技人才培养计划项目(黔科合人字(2005)0509号)；贵州省科技创新团队资助项目(黔科合人才团队(2013)4026)；贵州省重点学科建设资助项目(SZXK-201207-04)；遵义医学院优秀科研团队培育项目(遵医院办发[2012]12号) |
| 摘 要： | 背景：与传统水凝胶相比，智能水凝胶能够对外界刺激诸如温度、pH值、光、磁场等作出不同的应答表现，产生二级结构甚至化学结构的变化，自发组装形成有序的超分子结构，最终形成具有三维结构的凝胶。目的：综述智能水凝胶的研究现状及其在组织工程的应用。方法：应用计算机检索中国知网及PubMed 数据库从建库至2014年有关智能水凝胶在组织工程中应用的文献，检索关键词为“水凝胶，组织工程学，hydrogel，Tissue engineering”。结果与结论：智能水凝胶中包括温度敏感性、pH敏感性、光敏感性、磁敏感性及温度/pH双重敏感性水凝胶，其对于外界环境变化能自动感知并能作出响应性的反应，在药物递送系统、药物释放，修复和改善缺损组织等领域表现出一系列传统材料所没有的突出性能，尤其是在组织工程方面表现出相当的优越性：低免疫原性，减少了炎症和排斥作用；具备生物可降解性；能真正在三维尺度上模拟细胞所处微环境，从而利于细胞黏附、生长、迁移及分化等。中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程全文链接： |
| 关 键 词： | 生物材料 缓释材料 智能水凝胶 分类 组织工程 应用 综述 |
Application of intelligent hydrogel in the tissue engineering |
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| Zhang Ding-wen,Liu Yan-fei,Qi Peng,Liu Jian-guo. Application of intelligent hydrogel in the tissue engineering[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(12): 1944-1950. DOI: 10.3969/j.issn.2095-4344.2014.12.023 | |
| Authors: | Zhang Ding-wen Liu Yan-fei Qi Peng Liu Jian-guo |
| Affiliation: | 1School of Stomatology, Zunyi Medical University, Zunyi 563000, Guizhou Province, China 2The Key Laboratory of Cell Engineering in Guizhou Province, Zunyi 563000, Guizhou Province, China 3The Special Key Laboratory of Oral Diseases Research, Higher Education Institution in Guizhou Province, Zunyi 563000, Guizhou Province, China |
| Abstract: | BACKGROUND:Compared with traditional hydrogels, intelligent hydrogels can appear to exhibit different responses to different stimuli such as temperature, pH value, light, and magnetic field, produce two-stage structure and alter chemical structure to generate the ordered supramolecular structure by self-assembling, and ultimately cause the formation of the gel with three-dimensional structure.OBJECTIVE:To review the research status of intelligent hydrogels and its application in tissue engineering.METHODS:A computer-based search of CNKI and PubMed databases was performed to retrieve articles addressing intelligent hydrogels in tissue engineering published before 2014. The keywords were “hydrogel, tissue engineering” in Chinese and English.RESULTS AND CONCLUSION:Intelligent hydrogels are classified into temperature sensitivity, pH sensitivity, photosensitivity, magnetic susceptibility and temperature/pH dual responsive hydrogels. The change of the external environment can be automatically detected and responded. Intelligent hydrogels exhibit a series of outstanding performances in drug delivery systems, drug delivery, repair and improvement of defected tissues, which are not possessed by traditional materials. In particular, the intelligent hydrogels show considerable superiorities in tissue engineering, including low immunogenicity that reducing inflammation and rejection, biodegradability, realizing the three-dimensional scale simulation of cell microenvironment that is conducive to cell adhesion, growth, migration and differentiation. |
| Keywords: | biocompatible materials hydrogel tissue engineering review |
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