| 不同类型脑血管支架材料的特点及临床应用 |
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| 引用本文： | 梅敏杰. 不同类型脑血管支架材料的特点及临床应用[J]. 中国组织工程研究, 2014, 18(25): 4057-4061. DOI: 10.3969/j.issn.2095-4344.2014.25.021 |
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| 作者姓名： | 梅敏杰 |
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| 作者单位： | 沈阳市苏家屯区中心医院，辽宁省沈阳市 110101 |
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| 摘 要： | 背景：随着基础研究、临床应用，以及血管支架材料的不断发展，血管内支架置入治疗已被广泛应用于脑血管疾病治疗中。目的：综述这几种支架材料的特点及临床应用情况。方法：应用计算机检索CNKI数据库、万方数据库、PubMed数据库从建库到2014年3月的相关文献，中文检索关键词为“脑血管病，支架，生物相容性”，英文检索关键词为“cerebrovascular disease，stents，biocompatibility”。结果与结论：按释放方式可将脑血管支架分为球囊扩张式支架与自膨式支架。最初应用的支架材料主要为裸金属材料，由记忆合金、医用不锈钢、钽、钴、镍钛合金等制成。由于金属支架置入后会释放金属离子，易致血栓形成，再狭窄率高，后来对其表面进行改性，出现了涂层支架与覆膜支架。支架置入治疗的围手术期并发症主要有过度灌注综合征、急性血栓形成、血管破裂和远端血管栓塞、血管痉挛和穿刺相关并发症，远期并发症主要是支架置入后再狭窄问题。相信随着科技的进步，支架材料和制作工艺的不断改进，血管支架置入治疗将更加安全有效。中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程全文链接：
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| 关 键 词： | 生物材料 材料相容性 脑血管 支架置入 支架材料 生物相容性 |
| 收稿时间： | 2014-05-16 |
Characteristics and clinical application of different types of cerebral vascular scaffolds |
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| Mei Min-jie. Characteristics and clinical application of different types of cerebral vascular scaffolds[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(25): 4057-4061. DOI: 10.3969/j.issn.2095-4344.2014.25.021 |
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| Authors: | Mei Min-jie |
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| Affiliation: | Central Hospital of Sujiatun, Shenyang 110101, Liaoning Province, China |
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| Abstract: | BACKGROUND: With the development of the basic research and clinical application, as well as stent materials, endovascular stent therapy has been widely used in cerebrovascular disease treatment.OBJECTIVE:To review the characteristics and clinical application of several kinds of stent materials.METHODS: A computer-based search of CNKI, Wanfang, and PubMed databases was performed for relevant articles published before Match 2014 using the keywords of “cerebrovascular disease, stents, biocompatibility” in Chinese and English.RESULTS AND CONCLUSION: According to release methods, cerebrovascular stents can be divided into balloon expanding stents and self-expanding stents. The original materials are mainly bare metal materials, made of memory alloy, medical stainless steel, tantalum, cobalt, nickel and titanium alloy. Because the metallic stent after implantation will release metal ions that are easy to cause thrombosis and the restenosis rate is high, the coating stents and covered stents appear. Perioperative complications of stent implantation mainly include excessive perfusion syndrome, acute thrombosis, and vascular rupture and distal vascular embolization, vasospasm and puncture-related complications; the long-term complications are mainly restenosis after stent implantation. With the continuous improvement of stent materials and production techniques, vascular stent implantation will be more safe and effective. |
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| Keywords: | cerebrovascular trauma stents review |
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