| 经皮肺穿刺近距离放射治疗肺癌的疗效观察 |
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| 引用本文： | 王静,李振家,王显锋,明德国,迟翔宇. 经皮肺穿刺近距离放射治疗肺癌的疗效观察[J]. 山东大学学报(医学版), 2006, 44(10): 1017-1020 |
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| 作者姓名： | 王静 李振家 王显锋 明德国 迟翔宇 |
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| 作者单位： | 山东大学山东省立医院呼吸科,山东,济南,250021;山东省医学影像学研究所,山东,济南,250021 |
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| 基金项目： | 山东省卫生厅保健处资助项目 |
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| 摘 要： | 目的：探讨CT导向下经皮肺穿刺125Ｉ粒子近距离放疗对肺癌的近期疗效。方法：对53例肺癌患者在CT导向下经皮肺穿刺，瘤体内植入125Ｉ粒子。观察手术前后局部肿瘤大小、血常规、肝肾功能及免疫指标的变化。结果：对62个病灶行81次穿刺，术后1、2、3、6个月原发部位肿瘤治疗有效率分别为33.87%(21/62)、51.61%(32/62)、91.94%(57/62)、95.16%(59/62)。外周血常规、肝肾功能、免疫功能等指标手术前后无明显变化。5例出现气胸(6.17%)，9例发生咳血(11.11%)。植入后第6个月2例患者出现粒子丢失。结论：CT导向下经皮肺穿刺125Ｉ粒子近距离放疗对肺癌局部控制率高，对血常规、肝肾功能、免疫功能无明显影响,是一种疗效确切、安全简便的肿瘤微创治疗技术。
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| 关 键 词： | 碘-125 近距离放疗 肺肿瘤 |
| 文章编号： | 1671-7554（2006）10-1017-04 |
| 收稿时间： | 2006-07-10 |
| 修稿时间： | 2006-07-10 |
Brachytherapy by CT-guided percutaneous paracentesis implantation of iodine-125 seeds for lung cancer |
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| WANG Jing,LI Zhen-jia,WANG Xian-feng,MING De-guo,CHI Xiang-yu. Brachytherapy by CT-guided percutaneous paracentesis implantation of iodine-125 seeds for lung cancer[J]. Journal of Shandong University:Health Sciences, 2006, 44(10): 1017-1020 |
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| Authors: | WANG Jing LI Zhen-jia WANG Xian-feng MING De-guo CHI Xiang-yu |
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| Affiliation: | 1. Department of Respiratory Diseases， Shandong Provincial Hospital, Shandong, University, Jinan 250021, Shandong, China； 2. Shandong Institute of Medical Imaging， Jinan 250021, Shandong, China |
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| Abstract: | Objective: To explore the clinical value of ~(125) I interstitial brachytherapy by CT-guided percutanepus paracentesis.Methods: Implantation of iodine-125 seeds with implanting needle(18-gauge) by optical navigating system was carried out in fifty-three patients with lung cancer.After operation,the size of tumors and the changes of blood were observed.Results: The fifty-three patients,with sixty-two focuses,were given eighty-one punctures and observed for more than six months.Twelve of the patients were implanted again.The response rate of one,two,three and six months after operation was 33.87%(21/62),51.61%(32/62),91.94%(57/62) and 95.16%(59/62) respectively.There were no significant changes in peripheral blood cells,liver functions,renal functions,T cell subgroups and the activity of natural killer cells after operation.Pneumothorax and hemoptysis were seen in 5(6.17%,5/81) and(9(11.11%,)9/81) patients respectively.Conclusion: Brachytherapy by CT-guided percutaneous paracentesis implantation of iodine-125 seeds is effective and safe for the treatment of lung cancer.The complication is rare and easy to treat. |
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| Keywords: | Iodine-125 Brachytherapy Lung neoplasms |
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