| 高原低氧环境对兔牙周炎模型血清和牙龈组织中超氧化物歧化酶活力的影响 |
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| 引用本文： | Wu X,Huang J,Zhang G,Tan Y,Gao Y. 高原低氧环境对兔牙周炎模型血清和牙龈组织中超氧化物歧化酶活力的影响[J]. 华西口腔医学杂志, 2012, 30(3): 247-250. DOI: 10.3969/j.issn.1000-1182.2012.03.006 |
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| 作者姓名： | Wu X Huang J Zhang G Tan Y Gao Y |
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| 作者单位： | 1.第三军医大学新桥医院口腔科; 2.第三军医大学高原军事医学系, 重庆400037 |
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| 基金项目： | 全军医药卫生科研基金十一五资助项目(06MA184);全军医药卫生科研基金十二五资助项目(CWS11J320) |
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| 摘 要： | 目的观察高原低氧和平原常氧环境下兔牙周炎动物模型中超氧化物歧化酶（SOD）的活力情况,以探讨高原牙周病的发病机制。方法选取40只雄性白兔随机分为4组,即常氧对照组、常氧实验组（牙周炎动物模型）、低氧对照组、低氧实验组（牙周炎动物模型）。采用正畸结扎丝结扎下颌中切牙与牙周炎食谱的方法建立牙周炎动物模型。动态观察动物体重变化,实验8周后,检测各组动物牙周各项临床指标和血清、牙龈组织中的总SOD活力。结果8周时,与低氧对照组和常氧实验组相比,低氧实验组的总SOD活力下降（P＜0.05）,体重和牙周临床指标存在统计学差异（P＜0.01）。血清及牙龈组织中总SOD活力与附着丧失（AL）呈负相关（r值分别为-0.980和-0.804,P<0.01）,血清与牙龈组织中总SOD活力呈正相关（r=0.846,P<0.01）。结论高原低氧环境对全身生长状态和生物转化平衡会产生一定的影响,全身和局部的SOD活力明显下降,使机体尤其是局部牙周组织产生的大量超氧自由基堆积,加重了牙周组织的破坏。
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| 关 键 词： | 高原 低氧 牙周炎 超氧化物歧化酶 |
| 收稿时间： | 2012-06-25 |
| 修稿时间： | 2012-06-25 |
Effects of the activity of superoxide dismutase in blood serum and gingival tissues of rabbit in periodontitis model after hypoxia exposure at high altitude |
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| Wu Xi,Huang Jinging,Zhang Gang,Tan Yinghui,Gao Yuqi. Effects of the activity of superoxide dismutase in blood serum and gingival tissues of rabbit in periodontitis model after hypoxia exposure at high altitude[J]. West China journal of stomatology, 2012, 30(3): 247-250. DOI: 10.3969/j.issn.1000-1182.2012.03.006 |
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| Authors: | Wu Xi Huang Jinging Zhang Gang Tan Yinghui Gao Yuqi |
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| Affiliation: | 1. Dept. of Stomatology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China; 2. High Altitude Military Medical Faculty, The Third Military Medical University, Chongqing 400037, China |
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| Abstract: | Objective To observe the activity of superoxide dismutase(SOD) in rabbit periodontitis model in normoxia and hypoxia environment,and to research the pathogenesis of periodontal diseases at high altitude.Methods Fourty male rabbits were randomly divided into four groups: Normoxia control group,normoxia periodontitis group(periodontitis models),hypoxia control group,hypoxia periodontitis group(periodontitis models).The periodontitis models were established by ligating the two central incisors of mandible and raised by periodontitis diets.The weights of four groups were dynamically observed.After eight weeks,the clinical periodontal indexes and the activity of total-SOD(TSOD) in blood serum and gingival tissues in all groups were detected.Results The activity of T-SOD of hypoxia periodontitis group was significantly lower than normoxia periodontitis group and hypoxia control group(P<0.05),the weights and clinical periodontal indexes were also dramatically different(P<0.01).The activity of SOD in serum was positively correlated with the gingival tissues(r=0.846,P<0.01),and they both negatively correlated with AL(r=-0.980,-0.804,P<0.01).Conclusion The growth state of the body and the balance of bioconversion were affected in hypoxia environment when exposed at high altitude.The activity of SOD in total body and local tissues were decreased,thus the superoxide free radicals were accumulated in the body,especially in local periodontal tissues.Therefore it can ac-celerate and aggravate the destruction of periodontal tissues. |
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| Keywords: | high altitude hypoxia periodontitis superoxide dismutase |
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