| 甲型病毒性肝炎灭活疫苗应急接种效果研究 |
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| 引用本文： | 沈月根,顾谢君,周建红. 甲型病毒性肝炎灭活疫苗应急接种效果研究[J]. 疾病监测, 2008, 23(9): 551-553. DOI: 10.3784/j.issn.1003-9961.2008.09.009 |
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| 作者姓名： | 沈月根 顾谢君 周建红 |
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| 作者单位： | 1.浙江省嘉兴市秀洲区疾病预防控制中心，浙江 秀洲 314001 |
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| 摘 要： | 目的 了解甲型病毒性肝炎（甲肝）流行期间人群甲肝病毒抗体（抗 HAV）状况，评价甲肝灭活疫苗用于应急接种的保护效果。 方法 对甲肝患者及密切接触者进行流行病学调查，开展人群抗 HAV水平检测和进行甲肝灭活疫苗应急接种，在校学生直接接种，甲肝患者密切接触者筛选后接种， 观察疫苗安全性、 不同时间甲肝抗体反应及疫苗应急接种保护效果。 结果 流行期间人群抗 HAV总阳性率为77.82%，3365名在校学生和108名密切接触易感者接种疫苗后保护率达到100.00%；20岁年龄组发病构成比从接种疫苗前的38.89%下降到接种后2个月的19.44%；密切接触易感者接种后4周甲肝抗体阳转率为80.00%。结论 甲肝灭活疫苗具有安全性好、抗体产生快、应急接种保护效果好等特点，流行期间可考虑使用甲肝灭活疫苗控制疫情。
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| 关 键 词： | 甲型肝炎灭活疫苗 安全性 应急接种 保护效果 |
| 收稿时间： | 2008-03-20 |
Efficacy of emergency vaccination of inactivated hepatitis A vaccine |
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| SHEN Yue-gen,GU Xie-jun,ZHOU Jian-hong. Efficacy of emergency vaccination of inactivated hepatitis A vaccine[J]. Disease Surveillance, 2008, 23(9): 551-553. DOI: 10.3784/j.issn.1003-9961.2008.09.009 |
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| Authors: | SHEN Yue-gen GU Xie-jun ZHOU Jian-hong |
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| Affiliation: | 1.Xiuzhou District Center for Disease Control and Prevention of Jiaxing, Xiuzhou 314001, China |
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| Abstract: | Objective The study was conducted to detect the hepatitis A virus antibody(Anti-HAV) levels in general population during the hepatitis A epidemic,evaluate the efficacy of emergency vaccination of inactivated Hepatitis A vaccine.Methods Epidemiological survey was conducted among hepatitis A patients and close contacts,anti-HAV level detection was performed in the population,and the emergency vaccination of inactivated hepatitis A vaccine was implemented.3365 students received the vaccination directly in scho... |
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| Keywords: | inactivated hepatitis A vaccine safety emergency vaccination protective effect |
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