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| 线粒体酶活性及线粒体肿胀与不同运动强度的关系 | |
| 引用本文： | 徐 莉,曹 颖,张 敏. 线粒体酶活性及线粒体肿胀与不同运动强度的关系[J]. 中国组织工程研究, 2012, 16(42): 7893-7896. DOI: 10.3969/j.issn.2095-4344.2012.42.020 |
| 作者姓名： | 徐 莉 曹 颖 张 敏 |
| 作者单位： | 1天津体育学院,天津市3003812 天津中医药大学第一附属医院检验科,天津市 3001933武警后勤学院生化教研室,天津市 300162 |
| 摘 要： | 背景：关于不同运动强度对机体的影响早有研究,并且取得了不少有价值的成果。但是对于不同运动强度对线粒体Na+,K+-ATP酶、Ca2+-ATP酶活性以及线粒体肿胀程度影响的研究较少。目的：观察不同运动强度对大鼠骨骼肌线粒体Na+,K+-ATP酶和Ca2+-ATP酶以及线粒体肿胀的影响。方法：将24只SD大鼠随机分为正常对照组,中等强度运动组和高强度运动组。正常对照组大鼠正常笼内生活,不运动。另2组游泳训练方式,分别建立中强度和高强度运动模型,进行相应的运动锻炼,训练4周。结果与结论：中强度运动组线粒体Na+,K+-ATP酶、Ca2+-ATP酶活性与正常对照组相比均增高(P < 0.05),线粒体肿胀程度降低(P < 0.05);而高强度运动组线粒体Na+,K+-ATP酶、Ca2+-ATP酶活性与正常对照组相比均降低(P < 0.05),线粒体肿胀程度增大(P < 0.05)。实验结果表明中强度运动可以保护线粒体Na+,K+-ATP酶、Ca2+-ATP酶的活性,提高线粒体功能;而高强度运动则降低了线粒体的功能。 |
| 关 键 词： | 运动强度 线粒体 Na+ K+-ATP酶 Ca2+-ATP酶 线粒体肿胀 组织构建 |
| 收稿时间： | 2012-01-15 |
Effects of different exercise intensities on the activity of mitochondrial enzymes and mitochondrial swelling |
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| Xu Li,Cao Ying,Zhang Min. Effects of different exercise intensities on the activity of mitochondrial enzymes and mitochondrial swelling[J]. Chinese Journal of Tissue Engineering Research, 2012, 16(42): 7893-7896. DOI: 10.3969/j.issn.2095-4344.2012.42.020 | |
| Authors: | Xu Li Cao Ying Zhang Min |
| Affiliation: | 1Tianjin Institute of Physical Education, Tianjin 300381, China 2Clinical Laboratory, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 3Biochemistry Department, Logistics University of Chinese People’s Armed Police Forces, Tianjin 300162, China |
| Abstract: | BACKGROUND:There are many studies on the effects of different exercise intensities on the body, but studies about the effects of different exercise intensities on the activity of mitochondrial Na+, K+-adenosine triphosphatase (ATPase), Ca2+-ATPase and mitochondrial swelling are few.OBJECTIVE:To investigate the effects of different exercise intensities on the activity of mitochondrial Na+, K+-ATPase and Ca2+-ATPase, as well as mitochondrial swelling.METHODS:Twenty-four Sprague Dawley rats were randomly separated into three groups, namely, control, mid-intensity, high-intensity exercise groups. The control rats did not undergo swimming training, while the other two groups were given 4-week swimming exercises of different intensities.RESULTS AND CONCLUSION:Compared with the control group, the Na+, K+-ATPase and Ca2+-ATPase activities increased (P < 0.05) and the extent of mitochondrial swelling decreased (P < 0.05) in the mid-intensity exercise group, but opposite in the high-intensity exercise group. These findings indicate that mid-intensity exercise can protect the activity of mitochondrial Na+, K+-ATPase and Ca2+-ATPase and increase the function of mitochondria, but high-intensity exercise can decrease the function of mitochondria. |
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