| HGC-1在胃癌中的表达及其与临床病理特征和预后的关系 |
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| 引用本文： | 李一青1,李恩孝2,董丹凤2,吴胤英2,耿倩倩2. HGC-1在胃癌中的表达及其与临床病理特征和预后的关系[J]. 现代肿瘤医学, 2015, 0(23): 3462-3464. DOI: 10.3969/j.issn.1672-4992.2015.23.027 |
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| 作者姓名： | 李一青1 李恩孝2 董丹凤2 吴胤英2 耿倩倩2 |
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| 作者单位： | 1.西安电力中心医院，陕西 西安 7100322.西安交通大学医学院第一附属医院，陕西 西安 710061 |
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| 摘 要： | 目的:探讨胃癌患者HGC-1表达情况与临床病理特征及预后间的关系。方法:收集西安交通大学第一附属医院2007年8月-2010年10月所收治的100例胃癌患者的资料及肿瘤组织标本，并选取相应的100例正常黏膜组织及35例胃黏膜肠上皮化生组织作为对照组。采用免疫组织化学法检测三组中HGC-1蛋白表达情况。结果:胃癌组织中HGC-1蛋白表达明显高于正常组织（69.0%和8.0%，P<0.05）；HGC-1蛋白于胃黏膜肠上皮化生组织中表达阳性者为23例，阳性率为65.7%，明显高于正常黏膜中表达阳性者8例，阳性率8.0%，具有统计学差异，P<0.05。HGC-1蛋白表达上调与胃癌组织分化程度及PCNA有统计学意义，P<0.05；而与患者年龄、性别、肿瘤大小和部位、浸润深度、UICC分期、淋巴结转移及远处转移、M分期、脉管浸润无统计学意义,P>0.05。不同胃癌分化和PCNA患者的HGC-1蛋白表达有明显统计学差异。结论:胃癌发生与HGC-1存在关联，同时还可能是临床早期诊断及预后判断的重要指标。
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| 关 键 词： | HGC-1 胃癌 病理学 预后 |
HGC - 1 expression in gastric carcinoma and its relationship with clinicopathological fac-tors and prognosis |
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| Li Yiqing1,Li Enxiao2,Dong Danfeng2,Wu Yinying2,Geng Qianqian2. HGC - 1 expression in gastric carcinoma and its relationship with clinicopathological fac-tors and prognosis[J]. Journal of Modern Oncology, 2015, 0(23): 3462-3464. DOI: 10.3969/j.issn.1672-4992.2015.23.027 |
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| Authors: | Li Yiqing1 Li Enxiao2 Dong Danfeng2 Wu Yinying2 Geng Qianqian2 |
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| Affiliation: | 1.Xi'an Electric Center Hospital，Shaanxi Xi'an 710032，China；2.First Affiliated Hospital of Xi'an Jiaotong University，Shaanxi Xi'an 710061，China. |
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| Abstract: | Objective: To detect HGC-1 in patients with gastric and explore the relationship between the prognosis.Methods:To select 100 cases of gastric cancer patients and normal mucosa tissue,35 cases of gastric intestinal metaplasia as control group.Using immunohistochemical method to detect protein expression of HGC-1.Results:Gastric carcinoma HGC-1 protein expression was significantly higher than in normal tissues (69.0% and 8.0%，P<0.05).HGC-1 protein expression was positive in 23 cases of gastric intestinal metaplasia，the positive rate was 65.7%，significantly higher than normal mucosa eight cases positive expression，the positive rate was 8.0%，with statistical significance，P<0.05.HGC protein upregulated in gastric cancer tissue differentiation and PCNA related，P<0.05.There was not relation with age，gender，tumor size and location，depth of invasion，UICC stage，lymph node metastasis and distant metastasis，M stage，vascular invasion unrelated，P>0.05.Conclusion:Gastric cancer and HGC-1 exists close relation and also may be an important indicator of clinical diagnosis and prognosis. |
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| Keywords: | HGC-1 gastric cancer pathology prognosis |
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