Gender differences in colorectal cancer survival: A meta‐analysis |
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| Authors: | Yafan Yang Guiying Wang Jingli He Shuguang Ren Fengpeng Wu Jianfeng Zhang Feifei Wang |
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| Affiliation: | 1. Department of General Surgery, Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, China;2. Animal Center, Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, China;3. Department of Radiotherapy, Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, China |
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| Abstract: | A meta‐analysis was conducted to determine the influence of gender on overall survival (OS) and cancer‐specific survival (CSS) in colorectal cancer patients. Major databases were searched for clinical trials, which compare survival differences between male and female for colorectal cancer patients. A list of these studies and references, published in English and Chinese from 1960 to 2017, was obtained independently by two reviewers from databases such as PubMed, Medline, ScienceDirect, the China National Knowledge Infrastructure (CNKI) and Web of Science. Overall survival and cancer‐specific survival were compared using Review Manager 5.3. Females had significantly better OS (hazard ratio [HR] = 0.87; 95% confidence interval [CI] = 0.85–0.89) and CSS (HR = 0.92; 95% CI = 0.89–0.95) than males after meta‐analysis. These results suggest that gender seems to be a significant factor influencing survival results among colorectal cancer patients. |
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| Keywords: | colorectal cancer gender overall survival cancer‐specific survival OS CSS meta‐analysis |
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