THE VACUOLATING VIRUS OF MONKEYS : I. ISOLATION, GROWTH CHARACTERISTICS, AND INCLUSION BODY FORMATION |
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| Authors: | G.-D. Hsiung W. H. Gaylord Jr. |
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| Affiliation: | From the Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven |
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| Abstract: | A vacuolating virus isolated from uninoculated patas monkey kidney cultures was found to be serologically identical with SV40, a virus previously found in association with rhesus and cynomolgus monkeys. Detection of the patas virus was facilitated when patas cells were exposed to x-ray treatment. Rhesus monkey and human cells were relatively insusceptible to the virus, although it persisted in these cells for a long period of time. Distinct intranuclear inclusions were detected in infected patas cultures 2 to 3 days before cytoplasmic vacuoles were noticeable. Cultures previously infected with PA-57 virus did not affect yields of poliovirus, and doubly infected cells were easily distinguished in stained preparations. |
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