| 肝细胞癌患者PBMCs TLR 2/4表达和小肠细菌过度生长对TACE术后生存期的影响 |
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| 引用本文： | 许超,王森钰,罗援烨,陈王丽,周芸,盛以泉,郭满盈. 肝细胞癌患者PBMCs TLR 2/4表达和小肠细菌过度生长对TACE术后生存期的影响[J]. 实用肝脏病杂志, 2021, 24(2): 248-251. DOI: 10.3969/j.issn.1672-5069.2021.02.025 |
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| 作者姓名： | 许超 王森钰 罗援烨 陈王丽 周芸 盛以泉 郭满盈 |
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| 作者单位： | 313000 浙江省湖州市 解放军陆军第72集团军医院检验病理科(许超,罗援烨,陈王丽,周芸,盛以泉,郭满盈); 新疆医科大学第二附属医院核医学科(王森钰) |
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| 基金项目： | 浙江省医药卫生科研面上项目(编号:2018KY780)。 |
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| 摘 要： | 目的 探讨肝细胞癌(HCC)患者外周血单个核细胞(PBMCs)表面Toll样受体2(TLR2)和TLR4表达及小肠细菌过度生长(SIBO)对经肝动脉化疗栓塞(TACE)术后生存期的影响.方法 2013年1月 ～2016年6月我院诊治的47例HCC患者和同期在本院体检的100例健康人,所有患者接受TACE治疗.使用Cyt...
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| 关 键 词： | 肝细胞癌 肝动脉化疗栓塞术 外周血单个核细胞 Toll样受体 小肠细菌过度生长 生存 |
| 收稿时间： | 2020-07-16 |
Impact of PBMC surface TLR 2/4 expression and small intestinal bacterial overgrowth on survival in patients with hepatocellular carcinoma after TACE therapy |
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| Xu Chao,Wang Senyu,Luo Yuanye,et al. Impact of PBMC surface TLR 2/4 expression and small intestinal bacterial overgrowth on survival in patients with hepatocellular carcinoma after TACE therapy[J]. Journal of Clinical Hepatology, 2021, 24(2): 248-251. DOI: 10.3969/j.issn.1672-5069.2021.02.025 |
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| Authors: | Xu Chao Wang Senyu Luo Yuanye et al |
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| Affiliation: | Department of Pathology, 72nd Army Group, Huzhou 313000, Zhejiang Province, China |
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| Abstract: | Objective The aim of this study was to explore the impact of peripheral blood mononuclear cell(PBMC)surface Toll-like receptor(TLR)2/4 expression and small intestinal bacterial overgrowth(SIBO)on survival in patients with hepatocellular carcinoma(HCC)after transcatheter arterial embolization(TACE)therapy.Methods A retrospective clinical analysis was performed in 47 patients with HCC,who received TACE in our hospital between January 2013 and June 2016.100 healthy persons were recruited for the controls during the same period.The expression intensity(EI)of TLR2 and TLR4 on PBMC surface were detected by flow cytometry,and the SIBO was assessed based on lactulose hydrogen breath test(LHBT).patients with HCC was 66.0%,significantly.Results The SIBO positive rate in higher than 6.0%(P<0.05)in healthy persons,and the EI of TLR2+cells was(94.7±12.3)geometric mean fluorescence(GMF),significantly higher than【(26.4±4.2)GMF,P<0.05】,the EI of TLR4+cells was(43.1±8.7)GMF,significantly higher than【(16.8±4.5)GMF,P<0.05】in healthy persons;the EI of TLR2+cells in 31 HCC patients with SIBO positive was(109.3±16.8)GMF,greater than【(71.5±5.6)GMF,P<0.05】in 16 HCC patients with SIBO negative,and the EI of TLR4+cells was(46.7±7.1)GMF,greater than【(31.5±4.3)GMF,P<0.05】in patients with SIBO negative;six month after TACE,the EI of TLR2+cells in 23 but one patients who lost with long survival was(45.7±5.8)GMF,significantly weaker than【(65.6±12.5)GMF,P<0.05】,the EI of TLR4+cells was(21.5±4.3)GMF,significantly weaker than【(30.1±7.4)GMF,P<0.05】,and the SIBO positive rate was 4.4%,significantly lower than 62.5%(P<0.05)in 23 patients with short survival;the 3-year cumulative survival rate and 3-year cumulative event-free survival rate in 23 patients with TLR2 intensified expression were 17.4%and 13.0%,significantly lower than 52.2%and 43.5%(P<0.05)in 23 patients with weak TLR2 expression,and the 3-year cumulative survival rate and 3-year cumulative event-free survival rate in 23 patients with TLR4 strong expression were 13.0%and 8.7%,also significantly lower than 56.5%and 47.8%(P<0.05)in 23 patients with weak TLR4 expression,and they were 10.0%and 3.3%in 30 patients with SIBO positive,significantly lower than 81.3%and 75.0%(P<0.05)in 16 patients with SIBO negative.Conclusion The expression of TLR2 and TLR4 on PBMC surface and SIBO could impact the survival of patients with HCC after TACE,and the mechanism needs further investigation. |
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| Keywords: | Hepatocellular carcinoma Transcatheter arterial embolization Peripheral blood mononuclear cells Tolllike receptor Small intestinal bacterial overgrowth Survival |
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