| 慢加急性乙型肝炎肝衰竭患者发生感染和急性肾损伤危险因素分析 |
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| 引用本文： | 陈丹丹,龙志达,黄顺东,王文虎,尹明红,李忠斌. 慢加急性乙型肝炎肝衰竭患者发生感染和急性肾损伤危险因素分析[J]. 实用肝脏病杂志, 2021, 24(5): 717-720. DOI: 10.3969/j.issn.1672-5069.2021.05.028 |
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| 作者姓名： | 陈丹丹 龙志达 黄顺东 王文虎 尹明红 李忠斌 |
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| 作者单位： | 434000 湖北省荆州市 湖北中医药高等专科学校附属荆州市第二人民医院肝病二科(陈丹丹,黄顺东,王文虎,尹明红);华中科技大学同济医学院附属荆州医院肝胆外科(龙志达);解放军总医院第五医学中心肝硬化第二中心(李忠斌) |
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| 基金项目： | *2018年荆州市科研计划项目(编号:2018Wnkj09) |
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| 摘 要： | 目的 探讨慢加急性乙型肝炎肝衰竭(HBV-ACLF)患者发生感染和急性肾损伤(AKI)的危险因素.方法 2017年9月～2019年9月我科收治的HBV-ACLF患者102例,发生感染48例,发生AKI 32例,应用Logistics回归分析影响患者并发感染和AKI的相关影响因素.结果 感染组住院天数≥15 d、存在侵入...
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| 关 键 词： | 慢加急性肝衰竭 乙型肝炎 感染 急性肾损伤 危险因素 |
| 收稿时间： | 2020-10-13 |
Risk factors of infection and acute kidney injury in patients with acute-on-chronic hepatitis B liver failure |
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| Chen Dandan,Long Zhida,Huang Shundong,et al. Risk factors of infection and acute kidney injury in patients with acute-on-chronic hepatitis B liver failure[J]. Journal of Clinical Hepatology, 2021, 24(5): 717-720. DOI: 10.3969/j.issn.1672-5069.2021.05.028 |
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| Authors: | Chen Dandan Long Zhida Huang Shundong et al |
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| Affiliation: | Second Department of Liver Diseases, Affiliated Second People’s Hospital, Hubei Traditional Chinese Medical and Pharmaceutical School, Jingzhou 434000, Hubei Province, China |
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| Abstract: | Objective The aim of this study was to explore the risk factors of infection and acute kidney injury (AKI) in patients with acute-on-chronic hepatitis B liver failure (HBV-ACLF). Methods A total of 102 patients with HBV-ACLF were admitted to our hospital between September 2017 and September 2019, and the infections occurred in 48 patients and the AKI occurred in 32 patients. The related risk impacting factors of infection and AKI were analyzed by multivariate Logistic regression analysis. Results The percentages of hospital stay longer than 15 days, invasive check-up, gastrointestinal bleeding, ascites, hepatic encephalopathy and diabetes mellitus in patients with infections were 56.3%, 37.5%, 43.8%, 52.1%, 25.0% and 16.7%, significantly higher than 24.1%, 13.0%, 16.7%, 22.2%, 5.6% and 3.7% (P<0.05), serum bilirubin level was (310.2±42.2)μmol/L, significantly higher than , the MELD score was (26.1±4.6), significantly higher than , while serum albumin level was (30.4±1.1)g/L, significantly lower than in patients without infection; the multivariate Logistic regression analysis showed that the long hospital stay , invasive manipulation , gastrointestinal bleeding and hepatic encephalopathy were the independent risk factors for the occurrence of infections in patients with HBV-ACLF; the multivariate Logistic regression analysis demonstrated that the hepatic diabetes and gastrointestinal bleeding were the impacting factors for the happening of AKI in patients with HBV-ACLF. Conclusion The patients with HBV-ACLF have some risk factors for complications such as infections and AKI, and the long hospitalization, invasive manipulation, upper gastrointestinal hemorrhage and hepatic encephalopathy are the causative elements, which should be dealt with appropriately to improve the prognosis. |
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| Keywords: | Acute-on-chronic liver failure Hepatitis B Infections Acute kidney injury Risk factor |
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