| 慢加急性乙型肝炎肝衰竭患者血清自噬相关蛋白水平及其临床意义探讨 |
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| 引用本文： | 黄霜湘,姚朝光,蓝婧,欧琴,覃冬林,陈丽芬,黄洁婕. 慢加急性乙型肝炎肝衰竭患者血清自噬相关蛋白水平及其临床意义探讨[J]. 实用肝脏病杂志, 2021, 24(5): 721-724. DOI: 10.3969/j.issn.1672-5069.2021.05.029 |
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| 作者姓名： | 黄霜湘 姚朝光 蓝婧 欧琴 覃冬林 陈丽芬 黄洁婕 |
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| 作者单位： | 547000 广西壮族自治区河池市 右江民族医学院附属河池市人民医院消化内科 |
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| 基金项目： | *广西壮族自治区卫生健康委员会自筹科研基金课题(编号:Z20200690)作者单位:547000 广西壮族自治区河池市 右江民族医学院附属河池市人民医院消化内科 |
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| 摘 要： | 目的 探讨慢加急性乙型肝炎肝衰竭(HBV-ACLF)患者血清p62、微管相关蛋白1轻链3-Ⅱ(LC3-Ⅱ)和Beclin1水平变化及其临床意义.方法 2018年9月～2020年9月我院收治的HBV-ACLF患者60例和同期体检的健康人65例,计算终末期肝病模型评分(MELD),采用ELISA法测定血清p62、Becli...
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| 关 键 词： | 慢加急性肝衰竭 微管相关蛋白1轻链3-Ⅱ p62 Beclin1 预后 诊断试验 |
| 收稿时间： | 2020-01-06 |
Clinical significance of serum autophagy-related proteins in patients with hepatitis B virus-induced acute on chronic liver failure |
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| Huang Shuangxiang,Yao Chaoguang,Lan Jing,et al. Clinical significance of serum autophagy-related proteins in patients with hepatitis B virus-induced acute on chronic liver failure[J]. Journal of Clinical Hepatology, 2021, 24(5): 721-724. DOI: 10.3969/j.issn.1672-5069.2021.05.029 |
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| Authors: | Huang Shuangxiang Yao Chaoguang Lan Jing et al |
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| Affiliation: | Department of Gastroenterology, Hechi People's Hospital Affiliated to Youjiang Medical College of Nationalities, Hechi 547000, Guangxi Zhuang Autonomous Region, China |
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| Abstract: | Objective The aim of this study was to explore the clinical significance of serum p62, microtubule-associated protein 1 light chain 3-II (LC3-II) and Beclin1 in patients with hepatitis B virus infection-induced acute-on-chronic liver failure (HBV-ACLF). Methods Sixty patients with HBV-ACLF and 65 subjects who underwent physical examination in our hospital during the same period were recruited in this study between September 2018 and September 2020. The scores of model for end-stage liver disease (MELD) were calculated. Serum 62, Beclin1 and LC3-II levels were detected by ELISA. The predictive efficacy of serum p62, Beclin1 and LC3-II as well as MELD for prognosis of patients with HBV-ACLF was evaluated by area under the receiver operating characteristic curves (AUROC). Results At admission, serum LC3-Ⅱ and Beclin1 levels in patients with HBV-ACLF were (66.8±13.5)ng/mL and (11.7±3.6)ng/mL, both significantly higher than [(35.8±6.2)ng/mL and (8.2±2.9)ng/mL, respectively, P＜0.05], while serum p62 level was (2.5±0.9)ng/mL, significantly lower than [(4.5±1.6)ng/mL, P＜0.05] in the control; at day 90, 18 patients(30.0%)died; serum LC3-Ⅱ, Beclin1 levels and MELD score in dead patients at presentation were (76.25±12.1)ng/mL, (10.9±3.2)ng/mL and (20.1±3.3), all significantly higher than [(62.8±10.2)ng/mL,(13.4±3.5)ng/mL and (16.7±4.6), respectively, P＜0.05], while serum p62 level was (1.7±0.6)ng/mL, much lower than in the survivals; the ROC analysis showed that serum p62＜2.2 ng/mL, LC3-Ⅱ＞70.3 ng/mL and Beclin1＞12.6 ng/mL were set as the cut-off-value, the AUC were 0.856, 0.820 and 0.765 in predicting the poor prognosis of patients with HBV-ACLF, and the AUC of the three combination was 0.910, similar to 0.917 by MELD score when greater than 18.3 of it was set as the cut-off-value. Conclusion Serum p62, LC3-II and Beclin1 levels might be monitored and applied to predict the prognosis of patients with HBV-ACLF. |
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| Keywords: | Acute-on-chronic liver failure Microtubule-associated protein 1 light chain 3-II p62 Beclin1 Prognosis Diagnostic trial |
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