| 增强MRI T1 mapping定量评估慢性乙型肝炎患者肝纤维化程度效能分析 |
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| 引用本文： | 杨永汉,路萍,孟庆宁,张枫婕. 增强MRI T1 mapping定量评估慢性乙型肝炎患者肝纤维化程度效能分析[J]. 实用肝脏病杂志, 2021, 24(5): 685-688. DOI: 10.3969/j.issn.1672-5069.2021.05.020 |
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| 作者姓名： | 杨永汉 路萍 孟庆宁 张枫婕 |
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| 作者单位： | 810000 西宁市 青海省第五人民医院医学影像科(杨永汉,孟庆宁);核医学科(路萍);青海大学附属医院影像中心(张枫婕) |
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| 摘 要： | 目的 应用钆塞酸二钠增强MRI T1 mapping技术定量评估慢性乙型肝炎(CHB)患者肝纤维化程度.方法 2018年1月～2020年6月我院诊治的CHB患者74例,接受肝活检和钆塞酸二钠增强MR扫描,测量肝胆期信号强度(SI)、肝胆期T1值、相对增强(RE)和T1值变化率,绘制受试者工作特征曲线(ROC),计算曲线...
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| 关 键 词： | 慢性乙型肝炎 肝纤维化 钆塞酸二钠 磁共振成像 磁共振T1成像 诊断 |
| 收稿时间： | 2020-07-23 |
Quantitative evaluation of hepatic fibrosis in patients with chronic hepatitis B by enhanced MRI T1 mapping |
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| Yang Yonghan,Lu Ping,Meng Qingning,et al. Quantitative evaluation of hepatic fibrosis in patients with chronic hepatitis B by enhanced MRI T1 mapping[J]. Journal of Clinical Hepatology, 2021, 24(5): 685-688. DOI: 10.3969/j.issn.1672-5069.2021.05.020 |
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| Authors: | Yang Yonghan Lu Ping Meng Qingning et al |
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| Affiliation: | Department of Radiology, Fifth People's Hospital, Provincial Hospital, Xining 810000,Qinghai Province, China |
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| Abstract: | Objective The purpose of this study was to evaluate the hepatic fibrosis in patients with chronic Hepatitis B (CHB) by gadolinium-ethoxybenzyl- diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI T1 mapping. Methods A total of 74 patients with CHB were recruited between January 2018 and June 2020, and underwent Gd-EOB-DTPA enhanced MRI and liver biopsies. The hepatobiliary phase signal intensity (SI), hepatobiliary phase T1, relative enhancement (RE) and T1 changing rate of MRI were obtained. The ROC curve was drawn by MedCalc 15.1 statistical software, and the area under the curve (AUC) was calculated by Z test. The cut-off-value of each parameters were analyzed to evaluate the diagnostic efficacy. Results Out the 74 patients with CHB, the histopathological examination showed F0 liver fibrosis stage in 22 cases, F1 stage in 12, F2 stage in 15, F3 stage in 9 and F4 stage in 16; the SI of hepatobiliary phase, the T1 in hepatobiliary phase, the RE, and the T1 changing rate in 40 patients with significant liver fibrosis were(362.5±29.8), (418.5±41.2), (0.52±0.07) and (50.8±4.8)%, all significantly different compared to in 34 patents without significant liver fibrosis; the sensitivity and specificity of T1 changing rate in diagnosis of significant liver fibrosis were 77.6% and 93.2%, both significantly higher than by other three parameters. Conclusion The application of MRI T1 mapping technique in diagnosing liver fibrosis in patients with CHB is to some extent efficacious, which warrants further investigation. |
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| Keywords: | Hepatitis B Hepatic fibrosis Gadolinium-ethoxybenzyl- diethylenetriamine-pentaacetic acid MRI T1 mapping Diagnosis |
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