Pilot-scale production of group a and group C meningococcal polysaccharide immunogens |
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| Authors: | Berman S Altieri P L Groffinger A Lowenthal J P |
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| Affiliation: | Department of Biologics Research, Walter Reed Army Institute of Research, Washington, D.C. 20012. |
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| Abstract: | Methods have been developed for the pilot-scale production of group A and group C meningococcal polysaccharide immunogens based on the meningococcal strains, the medium, and the basic processing procedures used by Gotschlich et al. Physical and chemical assays on the final products obtained on a pilot-scale level indicate that these purified polysaccharides are entirely comparable to the Gotschlich preparations which proved to be immunogenic in man. |
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