| 细胞外基质与肿瘤干细胞相互作用的研究进展 |
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| 引用本文： | 王雨枫,徐岷. 细胞外基质与肿瘤干细胞相互作用的研究进展[J]. 现代肿瘤医学, 2021, 0(16): 2922-2926. DOI: 10.3969/j.issn.1672-4992.2021.16.035 |
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| 作者姓名： | 王雨枫 徐岷 |
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| 作者单位： | 江苏大学附属医院,江苏 镇江 212000 |
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| 基金项目： | National Natural Science Foundation of China(No.81672402）;国家自然科学基金（编号:81672402）;江苏省重点研发计划（社会发展）（编号:BE2018689） |
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| 摘 要： | 细胞外基质(extracellular matrix,ECM)是由蛋白质与糖类等生物大分子在细胞表面或细胞间构成的复杂网络结构.细胞外基质的过量沉积或结构形态异常是肿瘤微环境(tumor microenvironment,TME)的重要特征之一.肿瘤干细胞(cancer stem cells,CSC)指肿瘤内部一类具有...
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| 关 键 词： | 细胞外基质 肿瘤干细胞 肿瘤微环境 |
Research progress on the interaction between extracellular matrix and cancer stem cells |
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| WANG Yufeng,XU Min. Research progress on the interaction between extracellular matrix and cancer stem cells[J]. Journal of Modern Oncology, 2021, 0(16): 2922-2926. DOI: 10.3969/j.issn.1672-4992.2021.16.035 |
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| Authors: | WANG Yufeng XU Min |
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| Affiliation: | Affiliated Hospital of Jiangsu University,Jiangsu Zhenjiang 212000,China. |
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| Abstract: | The extracellular matrix (ECM) is a complex network structure composed of biological macromolecules such as proteins and carbohydrates on the cell surface or between cells.Excessive deposition of extracellular matrix or abnormal structure and shape is one of the important features of tumor microenvironment (TME).Cancer stem cells (CSC) refer to a subgroup of cells with the potential for immortal proliferation,self-renewal,and multidirectional differentiation within tumors,and are involved in tumor initiation,spread,metastasis and recurrence.Studies have shown that tumor occurrence is a process of mutual promotion and co-evolution by extracellular matrix and tumor stem cells.This article discusses the composition and characteristics of ECM and its influence on the biological behavior of CSC,with a view to seeking new directions for the clinical treatment of tumors. |
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| Keywords: | extracellular matrix cancer stem cells tumor microenvironment |
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