| Linc00673基因在非小细胞肺癌中的表达及临床意义 |
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| 引用本文： | 张依,杜维桓,纪红. Linc00673基因在非小细胞肺癌中的表达及临床意义[J]. 现代肿瘤医学, 2021, 0(11): 1903-1907. DOI: DOI:10.3969/j.issn.1672-4992.2021.11.016 |
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| 作者姓名： | 张依 杜维桓 纪红 |
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| 作者单位： | 航天中心医院老年医学二科,北京 100049 |
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| 摘 要： | 目的:本研究阐明了非小细胞肺癌(NSCLC)组织及其细胞系内基因长链非编码RNA00673(long in-tergenic non-coding RNA,LincRNA00673)的表达水平,以及Linc00673在肺癌中的临床意义及与患者预后的相关性.方法:利用逆转录-聚合酶链反应(qRT-PCR)的实验方法,检测...
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| 关 键 词： | 非小细胞肺癌 Linc00673 转移 预后 |
Expression of Linc00673 in non-small cell lung cancer and its clinical significance |
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| ZHANG Yi,DU Weihuan,JI Hong. Expression of Linc00673 in non-small cell lung cancer and its clinical significance[J]. Journal of Modern Oncology, 2021, 0(11): 1903-1907. DOI: DOI:10.3969/j.issn.1672-4992.2021.11.016 |
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| Authors: | ZHANG Yi DU Weihuan JI Hong |
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| Affiliation: | Department of Gereology,Aerospace Center Hospital,Beijing 100049,China. |
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| Abstract: | Objective:To elucidate the expression level of long intergenic non-coding RNA 00673 in non-small cell lung cancer (NSCLC) tissues and lung cancer cell lines,and the association between Linc00673 expression and survival,clinicopathological factors of patients with NSCLC.Methods:We firstly performed qRT-PCR to evaluate Linc00673 mRNA in lung cancer cell lines and lung cancer tissues.And we also analyzed the correlation between Linc00673 expression and the clinicopathological characteristics and prognosis of lung cancer.Results:Linc00673 expression in lung cancer cell lines was significantly higher than that in normal lung cell lines,and Linc00673 expression in lung cancer tissues was significantly higher than that in adjacent tissues(P＜0.01).Linc00673 expression was correlated with tumor differentiation(P=0.002),lymph node metastasis(P=0.001),distant metastasis(P=0.005),and clinical stage(P=0.001).The expression level of Linc00673 in lung cancer patients who smoke was higher than that in non-smoking lung cancer patients.High expression of Linc00673 in lung cancer was associated with poor prognosis (P＜0.01).Conclusion:Linc00673 expression is related to the development and prognosis of lung cancer,and Linc00673 has a significant value for assessing prognosis of NSCLC. |
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| Keywords: | NSCLC Linc00673 metastasis prognosis |
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