| miR-31和miR-1322在口腔鳞癌中的表达及与细胞增殖的关系 |
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| 引用本文： | 冯儒学1,蔡仁刚2,解丹丹3. miR-31和miR-1322在口腔鳞癌中的表达及与细胞增殖的关系[J]. 现代肿瘤医学, 2021, 0(10): 1683-1687. DOI: 10.3969/j.issn.1672-4992.2021.10.007 |
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| 作者姓名： | 冯儒学1 蔡仁刚2 解丹丹3 |
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| 作者单位： | 1.海南省干部疗养院（海南省老年病医院）口腔科,海南 海口 571100；2.文昌市人民医院口腔科,海南 文昌 571300；3.海南医学院第一附属医院营养科,海南 海口 570102 |
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| 摘 要： | 目的:检测微小RNA-31(microRNA-31,miR-31)和微小RNA-1322(microRNA-1322,miR-1322)在口腔鳞癌中的表达特征，分析其临床意义，探讨其与细胞增殖的关系。方法:选取2013年1月至2013年12月我院收治的75例口腔鳞癌患者为研究对象，选取肿瘤组织作为观察组，选取距肿物边缘>3 cm的正常口腔鳞状上皮组织作为对照组，应用实时荧光定量PCR法检测两组中miR-31和miR-1322的表达，应用免疫组化方法检测肿瘤组织中Ki67表达的增殖指数。结果:观察组中miR-31和miR-1322的表达明显高于对照组，观察组中miR-31和miR-1322的表达在不同分化程度、肿物最大径、淋巴结转移及TNM分期的表达中差异有统计学意义。生存分析显示二者的表达与生存时间相关。相关分析显示观察组中miR-31和miR-1322的表达均与增殖指数呈正相关性。结论:口腔鳞癌中miR-31和miR-1322高表达是肿瘤形成的促进因素。miR-31和miR-1322均对细胞增殖有促进作用，检测组织miR-31和miR-1322的表达对判断预后可能有一定价值。
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| 关 键 词： | 口腔鳞癌 miR-31 miR-1322 预后 |
Expression of miR-31 and miR-1322 and their relationship with cell proliferation in oral squamous cell carcinoma |
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| FENG Ruxue1,CAI Rengang2,XIE Dandan3. Expression of miR-31 and miR-1322 and their relationship with cell proliferation in oral squamous cell carcinoma[J]. Journal of Modern Oncology, 2021, 0(10): 1683-1687. DOI: 10.3969/j.issn.1672-4992.2021.10.007 |
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| Authors: | FENG Ruxue1 CAI Rengang2 XIE Dandan3 |
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| Affiliation: | 1.Department of Stomatology，Cadre Sanatorium of Hainan（Geriatric Hospital of Hainan）,Hainan Haikou 571100,China；2.Department of Stomatology,Wenchang People's Hospital,Hainan Wenchang 571300,China;3.Department of Clinical Nutrition,the First Affiliated Hospital of Hainan Medical College,Hainan Haikou 570102,China. |
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| Abstract: | Objective:To detect the expression of miR-31 and miR-1322 in oral squamous cell carcinoma,analyze their clinical significance,explore their relationship with cell proliferation.Methods:75 patients with oral squamous cell carcinoma admitted were selected from January 2013 to December 2013.Tumor tissue was selected as the observation group.Normal oral squamous epithelium tissue (distance of more than 3 cm from the edge of tumor) was selected as the control group.Real-time fluorescence quantitative PCR was used to detect the expression of miR-31 and miR-1322 in the two groups.Immunohistochemical method was used to detect the proliferation index of Ki67 in tumor tissue.Results:The expression of miR-31 and miR-1322 were significantly higher in the observation group than those in the control group.The expression of miR-31 and miR-1322 in observation group were significantly different in the degree of differentiation,max diameter,lymph node metastasis and TNM stage.Survival analysis showed that their expression was correlated with survival time.The correlation analysis showed that the expression of miR-31 and miR-1322 was positively correlated with the proliferation index.Conclusion:The higher expression of miR-31 and miR-1322 was a important factor to tumorigenesis.Both miR-31 and miR-1322 can promote cell proliferation.Expression of miR-31 and miR-1322 may be of some value in judging prognosis. |
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| Keywords: | oral squamous cell carcinoma miR-31 miR-1322 prognosis |
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