| 与交通有关苯暴露同儿童白血病风险关系的meta分析 |
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| 引用本文： | 孙原,迟美娜,曹俭,赵忠林,侯强. 与交通有关苯暴露同儿童白血病风险关系的meta分析[J]. 职业卫生与应急救援, 2021, 39(2): 136-140,147. DOI: 10.16369/j.oher.issn.1007-1326.2021.02.003 |
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| 作者姓名： | 孙原 迟美娜 曹俭 赵忠林 侯强 |
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| 作者单位： | 上海市化工职业病防治院, 上海 200041 |
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| 基金项目： | 上海市公共卫生体系建设三年行动计划（2020—2022）GWV-10.1-XK12;上海市化工职业病防治院课题2017ZFY09 |
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| 摘 要： | 目的 系统评价与交通有关的苯暴露与儿童白血病之间的关系.方法 搜索Web of Science和PubMed英文数据库,设置检索词为“childhood leukemia"或“childhood ALL”或“childhood AML”或“Benzene”或“traffic density”或“road density...
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| 关 键 词： | 交通 苯暴露 儿童 白血病 meta分析 |
| 收稿时间： | 2020-11-15 |
Traffic related benzene exposure and childhood leukemia risk: a meta analysis |
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| Abstract: | Objective To systematically evaluate the relationship between traffic related benzene exposure and childhood leukemia. Methods The English databases of web of science and PubMed were searched with the key words of "childhood leukemia", "childhood ALL", "childhood AML", "benzene", "traffic density", "road density" or "vehicle density". The relevant literatures that met the requirements were searched and meta-analysis was performed by Stata 15.0 software. Results A total of 579 literatures were screened and 21 case-control studies were included. There was moderate heterogeneity in 21 studies (I2=45%, P=0.014), so random effect model was used for statistical analysis. The results showed that the risk of childhood leukemia was not significantly associated to traffic related benzene exposure (pooled OR=1.03, 95% CI: 0.98-1.09, P=0.210). Further subgroup analysis showed that according to the NOS score, 12 studies with a score of ≥ 7 showed that traffic related benzene exposure had a statistically significant risk of childhood leukemia (pooled OR=1.04, 95% CI: 1.00-1.07, P=0.024). Funnel plot showed that there was no publication bias (Begg test, P=0.131). Conclusions There may be no correlation between traffic related benzene exposure and childhood leukemia, and the results need further high-quality prospective study to verify. |
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