| 盆腔MRI联合血清CA125、HE4检测对子宫内膜癌淋巴结转移的评估价值 |
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| 引用本文： | 包媛媛,洛若愚. 盆腔MRI联合血清CA125、HE4检测对子宫内膜癌淋巴结转移的评估价值[J]. 现代肿瘤医学, 2021, 0(10): 1752-1756. DOI: 10.3969/j.issn.1672-4992.2021.10.022 |
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| 作者姓名： | 包媛媛 洛若愚 |
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| 作者单位： | 武汉大学人民医院妇科,湖北 武汉 430060 |
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| 摘 要： | 目的:探讨盆腔MRI、血清癌抗原125(cancer antigen 125,CA125)、人附睾蛋白4(human epididymis protein 4,HE4)在子宫内膜癌(endometrial cancer,EC)淋巴结转移评估中的应用价值.方法:选取于本院行全面分期手术并经术后病理确诊为EC的137例患者...
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| 关 键 词： | 子宫内膜癌 盆腔MRI 癌抗原125 人附睾蛋白4 淋巴结转移 |
The value of pelvic MRI combined with serum CA125 and HE4 in evaluating lymph node metastasis of endometrial cancer |
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| BAO Yuanyuan,LUO Ruoyu. The value of pelvic MRI combined with serum CA125 and HE4 in evaluating lymph node metastasis of endometrial cancer[J]. Journal of Modern Oncology, 2021, 0(10): 1752-1756. DOI: 10.3969/j.issn.1672-4992.2021.10.022 |
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| Authors: | BAO Yuanyuan LUO Ruoyu |
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| Affiliation: | Department of Gynecology,Renmin Hospital of Wuhan University,Hubei Wuhan 430060,China. |
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| Abstract: | Objective:To investigate the value of pelvic MRI,serum cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) in the evaluation of lymph node metastasis in patients with endometrial cancer (EC).Methods:A total of 137 patients who underwent comprehensive staging and pathological diagnosis of EC in our hospital were retrospectively analyzed for the relationship between pelvic MRI,serum CA125,HE4 values and different pathological features.According to the lymph node metastasis group,calculate the sensitivity and specificity of the three single items and joint detection,and draw the CA125 and HE4 receiver operating characteristic curve (ROC).Results:MRI show high consistency in the detection of myometrial invasion,and the general consistency of cervical involvement and lymph node metastasis (Kappa values were 0.766,0.636,0.450).The levels of serum CA125 and HE4 were related to the depth of myometrial invasion and lymph node metastasis (P＜0.05),and were not related to the degree of cervical involvement(P＞0.05).Comparison of sensitivity and negative predictive value for predicting risk of lymph node metastasis:MRI+CA125+HE4 was the highest,while comparison of specificity,positive predictive value and accuracy:MRI was the highest.In the single test,the negative predictive values of the three were higher than the positive predictive values.The ROC curve of lymph node metastasis shows that the optimal cut-off values of CA125 and HE4 were 34.95 U/mL and 78.9 pmol/L.The area under the curve was compared:CA125+HE4>HE4>CA125.Conclusion:The single test of MRI,CA125 and HE4 show that the negative result is more reliable,and the positive detection rate is the highest in the joint evaluation.The overall diagnosis rate of MRI is the highest.Serum CA125≥34.95 U/mL and HE4≥78.9 pmol/L can be used as a reference for lymph node resection.HE4 predicts the value of metastasis better than CA125. |
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| Keywords: | endometrial cancer pelvic MRI cancer antigen 125 human epididymis protein 4 lymph node metastasis |
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