| 帕金森病患者血清同型半胱氨酸及血脂水平与脑白质病变的相关性研究 |
| |
| 引用本文： | 杨光,徐陈陈,王佳炜,丁庭庭,刘利君,刘飞飞,吴桐,王训. 帕金森病患者血清同型半胱氨酸及血脂水平与脑白质病变的相关性研究[J]. 中华全科医学, 2021, 19(9): 1451. DOI: 10.16766/j.cnki.issn.1674-4152.002083 |
| |
| 作者姓名： | 杨光 徐陈陈 王佳炜 丁庭庭 刘利君 刘飞飞 吴桐 王训 |
| |
| 作者单位： | 1.安徽医科大学第二附属医院神经内科，安徽 合肥 230000 |
| |
| 基金项目： | 国家自然科学基金项目81904086 |
| |
| 摘 要： | 目的 寻找帕金森病(PD)患者并发脑白质病(WML)的危险因素，以及同型半胱氨酸(Hcy)和血脂水平与WML的相关性。 方法 选择2015年1月—2020年1月安徽医科大学第二附属医院神经内科住院的PD患者200例为研究组，同期体检者110例为对照组。对其进行病史和人口学资料采集，测定各组生化指标水平。采用Fazekas分级将研究组分为4组。比较4组间临床资料及生化指标的差异，并应用logistic回归分析以及Spearman相关分析确定PD患者并发WML的影响因素。 结果 研究组Hcy的水平、WML的发生率及严重程度高于对照组，血脂水平低于对照组(均P＜0.05)；Hcy与WML严重程度呈正相关(r=0.556, P＜0.001)，在调整了人口学及混杂因素后，Hcy水平与WML严重程度仍呈正相关(r=0.400, P＜0.001)，Hcy预测PD患者发生WML的AUC为0.717(95%CI:0.673~0.861, P＜0.001)；WML严重程度与PD患者的H-Y评分、UPDRS运动评分呈正相关(r=0.460、0.360, 均P＜0.001)。 结论 血Hcy水平升高可能是PD患者并发WML的独立危险因素，HDL-C水平升高是PD患者并发WML的保护因素；Hcy或可作为PD患者并发WML的一种生物标志物。
|
| 关 键 词： | 帕金森病 同型半胱氨酸 脑白质病变 危险因素 |
| 收稿时间： | 2021-04-05 |
Study on the correlation between serum homocysteine and blood lipid levels and white matter lesions in patients with Parkinson's disease |
| |
| Affiliation: | Department of Neurology, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230000, China |
| |
| Abstract: | Objective To find out the risk factors of leukoencephalopathy (WML) in patients with Parkinson's disease (PD) and the correlation between homocysteine levels and WML. Methods From January 2015 to January 2020, 200 patients with PD who were hospitalized in the Department of Neurology of the Second Affiliated Hospital of Anhui Medical University were selected as the study group, and 110 patients with healthy physical examination during the same period were selected as the control group. Medical history and demographic data were collected. The level of biochemical indicators in each group were determined. The Fazekas classification was used to divide the study group into four groups. The differences in clinical data and biochemical indicators between the four groups were compared, and logistic regression analysis and Spearman correlation analysis were used to determine the influencing factors of PD patients with WML. Results The level of Hcy and the incidence and severity of WML in the study group were higher than those of the control group, and the blood lipid level was lower than that of the control group (all P < 0.05), the Hcy and WML were positively correlated (r=0.556, P < 0.001). After adjusting for demographics and confounding factors, the Hcy level was still positively correlated with the severity of WML (r=0.400, P < 0.001). The AUC of Hcy on WML in PD patients was 0.717 (95% CI: 0.673-0.861, P < 0.001); WML severity was positively correlated with PD patients' HY score and UPDRS exercise score (r=0.460, r=0.360, P < 0.001). Conclusion Elevated blood Hcy level may be an independent risk factor for PD patients with WML. Elevated HDL-C level is a protective factor for PD patients with WML. The Hcy may be used as a biomarker for PD patients with WML. |
| |
| Keywords: | |
|
| 点击此处可从《中华全科医学》浏览原始摘要信息 |
|
点击此处可从《中华全科医学》下载免费的PDF全文 |
|
