| 口服水飞蓟宾胶囊联合吡柔比星膀胱灌注对非肌层浸润性膀胱癌患者术后复发的影响 |
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| 引用本文： | 段万里,管振锋,赵华才,邓骞,程永毅,孙羿. 口服水飞蓟宾胶囊联合吡柔比星膀胱灌注对非肌层浸润性膀胱癌患者术后复发的影响[J]. 现代肿瘤医学, 2021, 0(10): 1728-1732. DOI: 10.3969/j.issn.1672-4992.2021.10.017 |
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| 作者姓名： | 段万里 管振锋 赵华才 邓骞 程永毅 孙羿 |
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| 作者单位： | 陕西省人民医院泌尿外科,陕西 西安 710068 |
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| 基金项目： | 陕西省重点项目-社会发展领域（编号:2017ZDXM-SF-050）;陕西省一般项目-青年项目（编号:2020JQ-945） |
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| 摘 要： | 目的:观察口服水飞蓟宾胶囊联合吡柔比星膀胱灌注对非肌层浸润性膀胱癌患者术后复发的影响.方法:将非肌层浸润性膀胱癌患者124例患者随机分为对照组62例和观察组62例,对照组给予吡柔比星膀胱灌注,观察组给予口服水飞蓟宾胶囊联合吡柔比星膀胱灌注.单因素分析性别、年龄、血尿、吸烟、肿瘤数目、肿瘤大小、肿瘤病理分级、肿瘤分期、水...
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| 关 键 词： | 非肌层浸润性膀胱癌 复发 水飞蓟宾 吡柔比星 影响因素 |
Effect of oral silibinin capsules combined with pirarubicin bladder infusion on the recurrence of bladder cancer in patients with non-muscle invasive bladder cancer |
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| DUAN Wanli,GUAN Zhenfeng,ZHAO Huacai,DENG Qian,CHENG Yongyi,SUN Yi. Effect of oral silibinin capsules combined with pirarubicin bladder infusion on the recurrence of bladder cancer in patients with non-muscle invasive bladder cancer[J]. Journal of Modern Oncology, 2021, 0(10): 1728-1732. DOI: 10.3969/j.issn.1672-4992.2021.10.017 |
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| Authors: | DUAN Wanli GUAN Zhenfeng ZHAO Huacai DENG Qian CHENG Yongyi SUN Yi |
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| Affiliation: | Department of Urology,Shaanxi Provincial People's Hospital,Shaanxi Xi'an 710068,China. |
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| Abstract: | Objective:To observe the effect of oral silibinin capsules combined with pirarubicin bladder infusion on the recurrence of bladder cancer in patients with non-muscle invasive bladder cancer.Methods:124 patients with non-muscle invasive bladder cancer were randomly divided into a control group of 62 cases and an observation group of 62 cases.The control group was given pirarubicin bladder infusion,and the observation group was given oral silibinin capsules combined with pirarubicin bladder infusion.Univariate analysis detected the effects of gender,age,hematuria,smoking,tumor number,tumor size,tumor pathological grade,tumor stage,silibinin combined with pirarubicin on bladder tumor recurrence.Factors that may affect tumor recurrence in univariate analysis were included in multivariate Cox regression analysis to determine independent factors that affect tumor recurrence.Results:The results of univariate analysis suggested that the number of tumors,tumor size,tumor pathological grade,tumor stage,silibinin combined with pirarubicin may be the factors affecting the recurrence of bladder tumors (P＜0.05).Multivariate Cox regression analysis showed multiple tumors and T1 were independent risk factors for non-muscle invasive bladder cancer (P＜0.05),and silibinin combined with pirarubicin was an independent protective factor for non-muscle invasive bladder cancer (P＜0.01).Conclusion:Oral silibinin capsules combined with pirarubicin bladder infusion has a better preventive effect on the recurrence of non-muscle invasive bladder cancer after TUR-BT,which can reduce the early recurrence rate of patients after surgery without increasing adverse reactions.It is relatively safe and worthy of clinical application. |
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| Keywords: | non-muscle invasive bladder cancer recurrence silibinin pirarubicin influencing factors |
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