| 血清几丁质酶1、鸢尾素表达与不同类型糖尿病视网膜病变患者微血管损伤的相关性 |
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| 引用本文： | 丁红萍,季晓燕,黄江,陈之阳. 血清几丁质酶1、鸢尾素表达与不同类型糖尿病视网膜病变患者微血管损伤的相关性[J]. 眼科新进展, 2021, 0(7): 664-667. DOI: 10.13389/j.cnki.rao.2021.0137 |
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| 作者姓名： | 丁红萍 季晓燕 黄江 陈之阳 |
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| 作者单位： | 215000 江苏省苏州市，苏州大学附属第二医院眼科 |
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| 摘 要： | 目的 研究血清几丁质酶1(CHIT1)、鸢尾素(Irisin)的表达与不同类型糖尿病视网膜病变(DR)患者微血管损伤的相关性.方法 选取我院2018年6月至2020年6月收治的106例糖尿病患者,根据不同疾病类型分为A组(增生型DR)、B组(非增生型DR)、C组(无视网膜病变).检测各组患者血清CHIT1、Irisin...
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| 关 键 词： | 糖尿病视网膜病变 几丁质酶1 鸢尾素 微血管损伤 |
Correlation between the expression of serum chitotriosidase and Irisin and microvascular injury in patients with different types of diabetic retinopathy |
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| DING Hongping,JI Xiaoyan,HUANG Jiang,CHEN Zhiyang. Correlation between the expression of serum chitotriosidase and Irisin and microvascular injury in patients with different types of diabetic retinopathy[J]. Recent Advances in Ophthalmology, 2021, 0(7): 664-667. DOI: 10.13389/j.cnki.rao.2021.0137 |
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| Authors: | DING Hongping JI Xiaoyan HUANG Jiang CHEN Zhiyang |
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| Affiliation: | Department of Ophthalmology,the Second Affiliated Hospital of Soochow University, Suzhou 215000,Jiangsu Province,China |
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| Abstract: | Objective To study the correlation between the expression of serum chitotriosidase (CHIT1) and irisin (Irisin) and microvascular damage in patients with different types of diabetic retinopathy (DR).Methods We selected 106 diabetic patients who admitted to our hospital from June 2018 to June 2020 and divided into group A (proliferative DR), group B (non-proliferative DR), and group C (no retinopathy) according to the type of disease. The levels of serum CHIT1 and Irisin and the proportions of peripheral blood endothelial cells (CEC), endothelial progenitor cells (EPC) and circulating progenitor cells (CPC) were detected, and the differences of indexes among the groups were compared. The correlation between the expression of serum CHIT1 and Irisin and CEC, EPC and CPC was analyzed by Pearson correlation. Logistic regression analysis was used to analyze the risk factors for proliferative DR in diabetic patients.Results The serum levels of CHIT1, Irisin and the proportion of CEC, EPC, CPC in peripheral blood cells were significantly different among the group A, group B and group C (all P<0.001). The serum levels of CHIT1 and the proportion of CEC in group A were significantly higher than those in group B and group C, while the levels of Irisin, the proportion of EPC and CPC in group A were significantly lower than those in group B and group C (all P<0.05). Pearson correlation analysis showed that the serum CHIT1 level was positively correlated with the ratio of CEC, but negatively correlated with EPC and CPC; the serum Irisin level was negatively correlated with the ratio of CEC but positively correlated with EPC and CPC (all P<0.001). The course of diabetes, serum CHIT1 and urinary microalbumin of patients with proliferative DR were significantly higher than those of patients with non-proliferative DR and no retinopathy, and the level of serum Irisin was significantly lower than that of patients with non-proliferative DR and no retinopathy (all P<0.05). Logistic regression analysis showed that duration of diabetes mellitus, CHIT1, Irisin and microalbuminuria were the influencing factors for DR in proliferative stage (all P<0.05).Conclusion The abnormal expression of CHIT1 and Irisin occurs in the serum of patients with type DR, which is closely related to microvascular injury, and it is the influencing factor for the progression of DR patients to proliferative type. |
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| Keywords: | diabetic retinopathy chitinase-1 Irisin microvascular injury |
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