| IDO在食管癌组织及血清中的表达及对进展的预测价值 |
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| 引用本文： | 黄磊,谭程,韩冰,吴建强,文智,陈佩锐,孙小康,郭向东,赵长明. IDO在食管癌组织及血清中的表达及对进展的预测价值[J]. 现代肿瘤医学, 2021, 0(17): 3031-3034. DOI: 10.3969/j.issn.1672-4992.2021.17.016 |
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| 作者姓名： | 黄磊 谭程 韩冰 吴建强 文智 陈佩锐 孙小康 郭向东 赵长明 |
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| 作者单位： | 德阳市人民医院心胸外科,四川 德阳 618000 |
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| 基金项目： | 四川省德阳科技局科技支撑计划（编号:2015SZ023） |
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| 摘 要： | 目的:通过观察吲哚胺2,3-双加氧酶(IDO)在肿瘤及血清中的表达,探讨其是否可以作为评价食管癌进展情况的预测指标.方法:选取本院2015年01月至2017年12月行食管癌根治术的患者88例,根据是否存在淋巴浸润分成2组,其中淋巴浸润包含淋巴管侵犯和淋巴结转移,另外选取20名健康志愿者作为对照组,采用免疫组化半定量法检...
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| 关 键 词： | 食管癌 吲哚胺2,3-双加氧酶 色氨酸 犬尿氨酸 淋巴结转移 |
Indoleamine 2,3-dioxygenase expression in tissue and serum of esophageal cancer and predictive value on progression |
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| HUANG Lei,TAN Cheng,HAN Bing,WU Jianqiang,WEN Zhi,CHEN Peirui,SUN Xiaokang,GUO Xiangdong,ZHAO Changming. Indoleamine 2,3-dioxygenase expression in tissue and serum of esophageal cancer and predictive value on progression[J]. Journal of Modern Oncology, 2021, 0(17): 3031-3034. DOI: 10.3969/j.issn.1672-4992.2021.17.016 |
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| Authors: | HUANG Lei TAN Cheng HAN Bing WU Jianqiang WEN Zhi CHEN Peirui SUN Xiaokang GUO Xiangdong ZHAO Changming |
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| Affiliation: | Department of Cardiothoracic Surgery,Deyang Municipal People's Hospital,Sichuan Deyang 618000,China. |
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| Abstract: | Objective:To evaluate whether serum and tumor indoleamine 2,3-dioxygenase activities can predict the progress of esophageal cancer.Methods:The study group consisted of 88 esophageal cancer patients.The patients were re-grouped according to the presence or absence of lymphatic invasion and lymph node metastasis.20 cancer-free subjects without any metabolic disturbances were included into the control group.Serum neopterin was measured by enzyme linked immunosorbent assay.Tissue sections from the studied tumors were re-examined histopathologically and were stained by immunohistochemistry with indoleamine-2,3-dioxygenase antibodies.Serum tryptophan (Trp) and kynurenine (Kyn) concentrations of all patients were determined by high performance liquid chromatography.Kyn/Trp was calculated and its correlation with serum neopterin was determined to estimate the serum indoleamine 2,3-dioxygenase activity.Results:Lymphatic invasion was present in 46 of 88 patients,of which only 24 patients had lymph node metastasis.22 patients with lymphatic invasion had no lymph node metastasis.Indoleamine-2,3-dioxygenase positive expression level was significantly higher in lymphatic invasion positive cancer group (42.78±6.43)% than negative patients (21.13±7.06)%,P<0.05.Indoleamine 2,3-dioxygenase expression was correlated both with the presence of lymphatic invasion and lymph node metastasis (P＜0.01 and P<0.05,respectively).Conclusion:Indoleamine-2,3-dioxygenase expression may indicate the presence of lymphatic invasion and lymph node metastasis and may be one of index in progression evaluation of esophageal cancer. |
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| Keywords: | esophageal cancer indoleamine-2 3-dioxygen tryptophan kynurenine lymph node metastasis |
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