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无创高频震荡通气在新生儿呼吸窘迫综合征治疗中的应用
引用本文:郭梅,王奇伟,刘鼎立,王磊. 无创高频震荡通气在新生儿呼吸窘迫综合征治疗中的应用[J]. 中华全科医学, 2021, 19(9): 1514-1517,1556. DOI: 10.16766/j.cnki.issn.1674-4152.002100
作者姓名:郭梅  王奇伟  刘鼎立  王磊
作者单位:1.阜阳市妇女儿童医院儿科, 安徽 阜阳 236000
基金项目:安徽省高校自然科学研究重点项目KJ2019A0342
摘    要:目的 探讨采用无创高频震荡通气与持续气道正压通气治疗新生儿呼吸窘迫综合征的临床效果、能否减少并发症发生率以及是否可以缩短住院时间和减少住院次数.方法 选择2018年1月-2019年12月期间在阜阳市妇女儿童医院新生儿重症监护室(NICU)的74例呼吸窘迫综合征新生儿,按照随机数表法分为无创高频(non-invasive...

关 键 词:新生儿呼吸窘迫综合征  无创正压通气  无创高频震荡通气
收稿时间:2020-11-23

Application of non-invasive high-frequency oscillatory ventilation in infant respiratory distress syndrome
Affiliation:Department of Pediatrics, Women and Children Hospital of Fuyang, Fuyang, Anhui 236000, China
Abstract:   Objective  To investigate the clinical effect of non-invasive high-frequency concussion ventilation and continuous positive airway pressure ventilation in the treatment of neonatal respiratory distress syndrome, whether it can reduce the incidence of complications and whether it can shorten the length of stay and reduce the number of hospitalisations.   Methods  A total of 74 cases of neonatal respiratory distress syndrome admitted in the NICU in our department from January 2018 to December 2019 were included. According to random number table method, the patients were divided into the non-invasive high-frequency group (NHFV group, 36 cases) and non-invasive positive pressure ventilation group (NCPAP group, 38 cases). The arterial blood oxygen levels, complications, duration of ventilator use and total length of hospital stay were compared before and after treatment at 12, 24, 48 and 72 h.   Results  PO2, A/APO2 and SaO2 in the NHFV group were higher than those in the NCPAP group at 12, 24, 48 and 72 h after respiratory support, and PaCO2 levels in the NHFV group at 12, 24, 48 and 72 h were lower than those in the NCPAP group, respectively (all P < 0.05). Both groups were treated and discharged, and no statistical significance was observed in the incidence of complications such as air leakage, persistent pulmonary hypertension, bronchopulmonary dysplasia, retinopathy, pulmonary haemorrhage, intracranial haemorrhage and other complications (all P>0.05). The duration of ventilator use and hospital stay in the NHFV group were shorter than those in the NCPAP group, and the difference was statistically significant (all P < 0.05).   Conclusion  Non-invasive high-frequency ventilation is an effective method for the treatment of neonatal respiratory distress syndrome. Compared with the traditional CPAP ventilation mode, it can significantly reduce CO2 retention, improve oxygenation index and shorten the length of hospital stay in children with respiratory distress syndrome, which is worthy of further clinical study. 
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