| MicroRNA-429在妇科恶性肿瘤中的研究进展 |
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| 引用本文： | 李栗扬,徐鹏,王蓓蒂,高爽,郭钰,匡野. MicroRNA-429在妇科恶性肿瘤中的研究进展[J]. 中华全科医学, 2021, 19(6): 1013-1016,1034. DOI: 10.16766/j.cnki.issn.1674-4152.001973 |
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| 作者姓名： | 李栗扬 徐鹏 王蓓蒂 高爽 郭钰 匡野 |
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| 作者单位： | 哈尔滨医科大学附属第二医院妇产科,黑龙江 哈尔滨 150086 |
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| 基金项目： | 吴阶平医学基金会临床科研课题项目320675018061 |
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| 摘 要： | 妇科恶性肿瘤是威胁女性健康的难题,早期诊断及治疗对于其预后来说意义重大.微小核糖核酸(mi-croRNA,miRNA)是参与细胞转录后调控的小型非编码RNA,在细胞正常生理过程及肿瘤发生发展中起关键作用.MicroRNA-429(miR-429)可抑制相关转录遏制物锌指E盒结合同源框1(Zinc E-box-bindi...
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| 关 键 词： | 微小核糖核酸-429 上皮-间质转化 卵巢癌 宫颈癌 子宫内膜癌 |
| 收稿时间： | 2020-08-08 |
Research progress of MicroRNA-429 in gynecological malignant tumors |
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| Affiliation: | Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China |
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| Abstract: | Gynecological malignant tumors is a problem that threatens women's health, of which early diagnosis and treatment are of great significance to the prognosis. MicroRNA (miRNA) is a small non-coding RNA involved in post-transcriptional regulation of cells, which plays a key role in the normal physiological processes of cells and the development of tumors. MicroRNA-429 (miR-429) can inhibit the expression of zinc E-box-binding homobox 1 (ZEB1) and ZEB2, which affects tumor progression and metastasis, and regulates Slug Gene expression in order to affects the expression of E-cadherin and Snail protein, and regulates the epithelial-mesenchymal transition (EMT) in tumors, which affects tumor migration, invasion, prognosis, and drug sensitivity. MiR-429 plays a tumor-promoting role in ovarian cancer and is not conducive to the prognosis, but its low expression is associated with low patient survival rates, and the differential expression of miR-429 was found in the ascites of ovarian cancer patients, which has potential clinical diagnostic significance. It plays a role in tumor suppression in cervical cancer role; plays a tumor-promoting role in endometrial cancer, and may have potential diagnostic value in endometrial cancer.The related literature on miR-429 and it's role in gynecological malignancies is reviewed, combined with tumor occurrence, invasion and other factors to discuss, comprehensively analyze the significance of miR-429 in gynecological malignancies, and for the further study significance in clinical application provides reference. |
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