| 五种肿瘤标志物联检在小细胞肺癌诊断中的价值 |
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| 引用本文： | 周建平1,宋晓龙1,王改琴1,杨 茹1,李玉芳1,刘延梅2. 五种肿瘤标志物联检在小细胞肺癌诊断中的价值[J]. 现代肿瘤医学, 2021, 0(15): 2635-2638. DOI: DOI:10.3969/j.issn.1672-4992.2021.15.014 |
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| 作者姓名： | 周建平1 宋晓龙1 王改琴1 杨 茹1 李玉芳1 刘延梅2 |
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| 作者单位： | 1.陕西省人民医院放免中心，陕西 西安 710068;2.陕西省人民医院西院二病区，陕西 西安 710068 |
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| 基金项目： | 陕西省自然科学基础研究计划(编号:2017JM8174) |
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| 摘 要： | 目的:探讨五种肿瘤标志物［癌胚抗原（CEA）、神经元特异性烯醇化酶（NSE）、细胞角蛋白19片段（Cyfra21-1）、胃泌素释放肽前体（ProGRP）、人附睾蛋白4（HE4）］联合检测在不同分期小细胞肺癌诊断中的价值。方法:应用电化学发光法分别检测117例小细胞肺癌患者（Ⅰ期23例、Ⅱ期26例、Ⅲ期39例、Ⅳ期29例），70例肺部良性疾病患者及120名健康体检者血清中CEA、NSE、Cyfra21-1、ProGRP和HE4水平。结果:小细胞肺癌组五种肿瘤标志物水平均高于健康对照组和肺部良性病变组，差异有统计学意义（P＜0.05）；血清ProGRP浓度随疾病进展而明显升高，其表达水平与临床分期密切相关（P＜0.05）。血清HE4表达水平Ⅱ期高于Ⅰ期，Ⅳ期高于Ⅲ期，差异有统计学意义（P＜0.05）；五种肿瘤标志物联合检测诊断小细胞肺癌的效能最高，各单项指标诊断效能由高到低依次为AUCProGRP 0.91>AUCHE4 0.89>AUCNSE 0.80>AUCCyfra21-1 0.64>AUCCEA 0.60。结论:血清ProGRP是诊断不同分期SCLC良好的肿瘤标志物，在SCLC早期也具有较高的灵敏度和特异度，血清HE4和NSE是较好的补充，多肿瘤标志物联合检测仍是提高诊断效能的最佳选择。
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| 关 键 词： | 肿瘤标志物 联合检测 小细胞肺癌 不同分期 |
The value of diagnosis of small cell lung cancer with combined detection of five tumor markers |
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| ZHOU Jianping1,SONG Xiaolong1,WANG Gaiqin1,YANG Ru1,LI Yufang1,LIU Yanmei2. The value of diagnosis of small cell lung cancer with combined detection of five tumor markers[J]. Journal of Modern Oncology, 2021, 0(15): 2635-2638. DOI: DOI:10.3969/j.issn.1672-4992.2021.15.014 |
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| Authors: | ZHOU Jianping1 SONG Xiaolong1 WANG Gaiqin1 YANG Ru1 LI Yufang1 LIU Yanmei2 |
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| Affiliation: | 1.Department of Radioimmunity Center,Shaanxi Provincial People's Hospital,Shaanxi Xi'an 710068,China;2.the Second Endemic Area of the West Department,Shaanxi Provincial People's Hospital,Shaanxi Xi'an 710068,China. |
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| Abstract: | Objective:To explore the value of the combined detection of five tumor markers (CEA,NSE,Cyfra21-1,ProGRP and HE4) in the diagnosis of small cell lung cancer in different stages.Methods:The levels of serum CEA,NSE,Cyfra21-1,ProGRP and HE4 in 117 patients with small cell lung cancer(23 cases of Ⅰ stage,26 cases of Ⅱ stage,39 cases of Ⅲ stage and 29 cases of Ⅳ stage),70 patients with benign lung diseases and 120 persons undergoing physical examination were measured by automatic electrochemiluminescence analyzer.Results:The levels of five tumor markers in patients with small cell lung cancer were significantly higher than those in patients with healthy controls and benign lung diseases(P＜0.05).The level of serum ProGRP was significantly increased with the progress of disease and it was closely correlated with clinical stages(P＜0.05).The level of serum HE4 in patients with Ⅱstage was significantly higher than those in patients with Ⅰ stage and that in patients with Ⅳ stage was significantly higher than that in patients with Ⅲ stage(P＜0.05).The efficiency was the highest by combining detection with five tumor markers in diagnosis of small cell lung cancer.Conclusion:Serum ProGRP is a good tumor markers in diagnosis of SCLC in different stages,which also has high sensitivity and specificity in the early stages of SCLC.Serum HE4 and NSE are good supplements.Combined detection of multiple tumor markers is still the best choice to improve the diagnostic efficiency. |
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| Keywords: | tumor marks combined detection SCLC different stages |
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