| circ_XPO1在骨肉瘤组织和外周血中的表达及临床意义 |
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| 引用本文： | 杨庆磊1,刘国强1,尹庆水2. circ_XPO1在骨肉瘤组织和外周血中的表达及临床意义[J]. 现代肿瘤医学, 2021, 0(20): 3623-3627. DOI: 10.3969/j.issn.1672-4992.2021.20.024 |
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| 作者姓名： | 杨庆磊1 刘国强1 尹庆水2 |
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| 作者单位： | 1.粤北人民医院创伤骨科,广东 韶关 512000;2.中国人民解放军南部战区总医院骨科,广东 广州 510010 |
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| 基金项目： | 广东省韶关市科技计划项目（编号:2019sn017）;广东省韶关市卫生计生科研项目（编号:Y19018） |
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| 摘 要： | 目的:检测 circ_XPO1在骨肉瘤患者组织和外周血中的表达水平,探讨其临床意义。方法:qRT-PCR检测39例骨肉瘤患者肿瘤组织、瘤旁组织及外周血中circ_XPO1的表达水平和24例健康志愿者外周血中circ_XPO1的表达水平,绘制ROC曲线分析circ_XPO1对骨肉瘤的诊断价值,多因素回归分析研究 circ_XPO1与肿瘤病理指标的相关性,通过生存曲线分析和COX回归分析研究 circ_XPO1对骨肉瘤患者预后的影响。结果:骨肉瘤患者外周血中circ_XPO1的表达水平比健康志愿者显著升高,而骨肉瘤患者的肿瘤组织和外周血中circ_XPO1的表达量均比瘤旁组织显著升高。绘制ROC曲线,骨肉瘤患者外周血中circ_XPO1表达水平的AUC为0.857 9。根据外周血的circ_XPO1表达水平将39例骨肉瘤患者分为circ_XPO1高表达组和circ_XPO1低表达组,多因素回归分析显示外周血circ_XPO1的高表达与组织学Price分级和肺部转移呈正相关;绘制生存曲线分析,外周血circ_XPO1高表达组的5年总生存率显著降低,COX回归分析结果提示外周血circ_XPO1高表达是影响骨肉瘤患者生存率的独立危险因素。结论:骨肉瘤患者的外周血和肿瘤组织中circ_XPO1的表达上调,外周血中circ_XPO1的高表达对骨肉瘤有较高的诊断价值,并且circ_XPO1上调越明显,提示临床病情越严重,预后越差。
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| 关 键 词： | 骨肉瘤 circ_XPO1 临床意义 |
The expression and clinical significance of circ_XPO1 in osteosarcoma and peripheral blood |
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| YANG Qinglei,LIU Guoqiang,YIN Qingshui. The expression and clinical significance of circ_XPO1 in osteosarcoma and peripheral blood[J]. Journal of Modern Oncology, 2021, 0(20): 3623-3627. DOI: 10.3969/j.issn.1672-4992.2021.20.024 |
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| Authors: | YANG Qinglei LIU Guoqiang YIN Qingshui |
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| Affiliation: | 1.Department of Trauma Orthopedics,Yuebei People's Hospital,Guangdong Shaoguan 512000,China;2.Department of Orthopaedics,General Hospital of the Southern Theater of PLA,Guangdong Guangzhou 510010,China. |
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| Abstract: | Objective:To detect the expression level of circ_XPO1 in tissues and peripheral plasma of patients with osteosarcoma,and explore its clinical significance.Methods:qRT-PCR was used to detect the expression level of circ_XPO1 in tumor tissues,adjacent tissues and peripheral plasma of 39 patients with osteosarcoma,and the expression level of peripheral plasma circ_XPO1 in 24 healthy volunteers.ROC curve was drawn to analyze the diagnostic value of circ_XPO1 for osteosarcoma.Multivariate regression analysis was used to study the correlation between circ_XPO1 and tumor pathological indicators.Survival curve analysis and COX regression analysis was used to study the effect of circ_XPO1 on the prognosis of patients with osteosarcoma.Results:The expression level of circ_XPO1 in peripheral plasma of osteosarcoma patients was significantly higher than that of healthy volunteers.Compared with adjacent tissues,the expression level of circ_XPO1 in tumor tissues and peripheral plasma of osteosarcoma patients was significantly increased.The AUC of the peripheral plasma circ_XPO1 expression of osteosarcoma patients in ROC curve was 0.857 9.According to the expression level of peripheral plasma circ_XPO1,39 patients with osteosarcoma were divided into circ_XPO1 high expression group and circ_XPO1 low expression group.Multivariate regression analysis showed that the high expression of peripheral plasma circ_XPO1 was positively correlated with histological Price grade and lung metastasis.Survival curve analysis showed that the 5-year overall survival rate of the high expression group of peripheral plasma circ_XPO1 was significantly reduced.COX regression analysis indicated that the high expression of peripheral plasma circ_XPO1 was an independent risk factor affecting the survival of osteosarcoma patients.Conclusion:The expression of circ_XPO1 in peripheral plasma and tumor tissues of osteosarcoma patients is up-regulated.The high expression of peripheral plasma circ_XPO1 has a good diagnostic value for osteosarcoma.The more up-regulated circ_XPO1 expression,the worse the clinical condition,and the worse the prognosis. |
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| Keywords: | osteosarcoma circ_XPO1 clinical significance |
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