| 联合用药治疗脊髓损伤中重度痉挛的临床观察 |
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| 引用本文： | 刘根林,周红俊,李建军,郑樱,郝春霞,张缨,卫波,王一吉,康海琼,汪家琮. 联合用药治疗脊髓损伤中重度痉挛的临床观察[J]. 中国康复理论与实践, 2012, 18(11): 1080-1081 |
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| 作者姓名： | 刘根林 周红俊 李建军 郑樱 郝春霞 张缨 卫波 王一吉 康海琼 汪家琮 |
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| 作者单位： | 1.首都医科大学康复医学院，北京市100068；2.中国康复研究中心北京博爱医院，北京市100068。 |
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| 基金项目： | 中国康复研究中心科研基金资助项目(2009-2) |
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| 摘 要： | 目的观察联合应用巴氯芬、替扎尼定和乙哌立松治疗脊髓损伤中重度痉挛患者的临床效果。方法住院脊髓损伤中重度痉挛患者18 例，采用2 种或3 种药物联合应用，所有患者连续服药2 个月，并随访4 个月以上。采用改良Ashworth 评分进行评定，同时观察痉挛缓解持续时间及血压、血尿常规和肝肾功能。结果重度痉挛患者16 例中，3 例改良Ashworth 评分降低3 级，12 例降低2 级，1 例降低1 级，伴神经痛明显减轻；2 例中度痉挛患者均降低1 级，伴神经痛明显减轻。服药后肝肾功能未见异常，出现轻度嗜睡2 例。结论联合用药对脊髓损伤中重度痉挛患者的解痉效果明显，副作用小。
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| 关 键 词： | 脊髓损伤 痉挛 巴氯芬 替扎尼定 乙哌立松 康复 |
| 收稿时间： | 2012-07-02 |
Effect of Combination of Baclofen,Tizanidine and Eperisone on Moderate to Severe Spasticity after Spinal Cord Injury |
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| LIU Gen-lin,ZHOU Hong-jun,LI Jian-jun,et al.. Effect of Combination of Baclofen,Tizanidine and Eperisone on Moderate to Severe Spasticity after Spinal Cord Injury[J]. Chinese Journal of Rehabilitation Theory and Practice, 2012, 18(11): 1080-1081 |
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| Authors: | LIU Gen-lin ZHOU Hong-jun LI Jian-jun et al. |
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| Affiliation: | Capital Medical University School of Rehabilitation Medicine, Beijing Bo'ai Hospital, China Rehabilitation Research Centre, Beijing 100068, China |
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| Abstract: | Objective To investigate the effect of combination of baclofen, tizanidine and eperisone on moderate or severe spasticity after spinal cord injury. Methods 18 inpatients with moderate (n=2) or severe (n=16) spasticity after spinal cord injury were treated with combination of 2 or 3 kinds of drugs for 2 months, and followed up for at least 4 months with modified Ashworth scale (MAS). Their blood pressure, blood and urine routine, liver and kidney function were observed. Results Among the 16 cases of severe spasticity (MAS≥3), MAS reduced 3 grades in 3 cases, 2 grades in 12 cases, 1 grade in 1 case, with alleviation of phantom pain. For the cases of moderate spasticity (MAS=2), the MAS reduced 1 grade with alleviation of phantom pain. Slightly drowsiness was observed in 2 cases. No hepatic or renal dysfunctions was found. Conclusion Combination of baclofen, tizanidine and eperisone is effective on moderate or severe spasticity after spinal cord injury with limited side-effects. |
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| Keywords: | spinal cord injury spasticity baclofen tizanidine eperisone rehabilitation |
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