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Cutaneous CD30 positive lymphoproliferative disorders with coexistent epithelial neoplasms: Report of two cases |
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| Authors: | Kate M Newland Christopher J McCormack H Miles Prince Stephen Lade |
| Affiliation: | 1. Department of Dermatology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;2. Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;3. Department of Anatomical Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia |
| Abstract: | Primary cutaneous large cell anaplastic lymphoma (C‐ALCL) and lymphomatoid papulosis (LyP) are cutaneous CD30+ lymphoproliferative disorders (CD30+ LPD). An association with CD30+ LPD and pseudoepitheliomatous hyperplasia has been recognized. Additionally, rare reports of epithelial neoplasms such as keratoacanthomas and squamous cell carcinomas (SCC) occurring in association with both C‐ALCL and LyP have been reported. We report two cases of CD30+ LPD with associated epithelial neoplasms; one patient with a primary cutaneous CD30+ LPD and SCC identified within the same lesion, and the other with a keratoacanthoma arising in a lesion of LyP. The pathogenesis of this association is poorly understood although various hypotheses exist. Awareness of the coexistence of these entities will avoid misdiagnosis and incorrect treatment. |
| Keywords: | cutaneous CD30+ lymphoproliferative disorder keratoacanthoma lymphomatoid papulosis primary cutaneous large cell anaplastic lymphoma pseudoepitheliomatous hyperplasia |