Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV |
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| Authors: | DeBord Kristin L Anderson Deborah M Marketon Melanie M Overheim Katie A DePaolo R William Ciletti Nancy A Jabri Bana Schneewind Olaf |
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| Affiliation: | Department of Microbiology, University of Chicago, 920 E. 58th Street, Chicago, Illinois 60637, USA. |
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| Abstract: | In contrast to Yersinia pestis LcrV, the recombinant V10 (rV10) variant (lacking residues 271 to 300) does not suppress the release of proinflammatory cytokines by immune cells. Immunization with rV10 generates robust antibody responses that protect mice against bubonic plague and pneumonic plague, suggesting that rV10 may serve as an improved plague vaccine. |
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