Effect of hepatitis B virus on steatosis in hepatitis C virus co‐infected subjects: A multi‐centre study and systematic review |
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| Authors: | N. Goossens C. de Vito A. Mangia S. Clément G. Cenderello F. Barrera R. D'Ambrosio N. Coppola R. Zampino M. Stanzione L. E. Adinolfi H. Wedemeyer N. Semmo B. Müllhaupt D. Semela R. Malinverni D. Moradpour M. Heim G. Trincucci L. Rubbia‐Brandt F. Negro |
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| Affiliation: | 1. Division of Gastroenterology and Hepatology, Geneva University Hospitals, Geneva, Switzerland;2. Division of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland;3. Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy;4. Division of Infectious Diseases, Galliera Hospital, Genova, Italy;5. Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, NSW, Australia;6. Division of Gastroenterology and Hepatology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, Italy;7. Department of Mental Health and Preventive Medicine, Second University of Naples, Napoli, Italy;8. Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Napoli, Italy;9. Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Napoli, Italy;10. Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany;11. German Center for Infectious Disease Research, Hannover‐Braunschweig, Germany;12. Hepatology, Department of Clinical Research, University of Bern, Bern, Switzerland;13. Division of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland;14. Division of Gastroenterology, Kantonsspital St. Gallen, St. Gallen, Switzerland;15. H?pital Neuchatelois, Neuchatel, Switzerland;16. Division of Gastroenterology and Hepatology, University Hospital Lausanne, Lausanne, Switzerland;17. Division of Gastroenterology and Hepatology, University Hospital Basel, Basel, Switzerland;18. Department of Pathology and Immunology, Geneva University, Geneva, Switzerland |
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| Abstract: | It remains unclear whether hepatitis B virus (HBV) infection may modify the severity of viral steatosis in patients coinfected with chronic hepatitis C virus (HCV). We examined the influence of coinfection with HBV on prevalence of steatosis in chronic hepatitis C in a multi‐centre cohort of HBV‐HCV subjects, and by performing a systematic review and meta‐analysis of the literature. We centrally and blindly assessed steatosis prevalence and severity in a cohort of HBV‐HCV coinfected subjects compared to HCV and HBV monoinfected controls and we performed a systematic review of studies addressing the prevalence of steatosis in HBV‐HCV subjects compared to HCV controls. In the clinical cohort, we included 85 HBV‐HCV, 69 HBV and 112 HCV subjects from 16 international centres. There was no significant difference in steatosis prevalence between the HBV‐HCV and the HCV groups (33% vs 45%, P = .11). In subgroup analysis, lean HBV‐HCV subjects with detectable HBV DNA had less steatosis than lean HCV subjects matched for HCV viremia (15% vs 45%, P = .02). Our literature search identified 5 additional studies included in a systematic review. Overall, prevalence of steatosis > 5% was similar in HBV‐HCV infection compared to HCV (pooled odds ratio [OR] 0.91, 95% CI 0.53‐1.6) although there was significant heterogeneity (I2 69%, P = .007). In conclusion, although the prevalence of steatosis is similar in HBV‐HCV compared to HCV subjects, our analysis suggests that there may be an inhibitory effect of HCV‐induced steatogenesis by HBV in certain subgroups of patients. |
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| Keywords: | hepatitis C virus hepatitis C‐hepatitis B coinfection metabolic syndrome steatosis |
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