| IL28RA在胃癌组织中的表达及其与临床病理特征和预后的关系 |
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| 引用本文： | 苏 晨,张国山,潘家超,郑雅文. IL28RA在胃癌组织中的表达及其与临床病理特征和预后的关系[J]. 现代肿瘤医学, 2023, 0(13): 2486-2490. DOI: 10.3969/j.issn.1672-4992.2023.13.021 |
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| 作者姓名： | 苏 晨 张国山 潘家超 郑雅文 |
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| 作者单位： | 山东第一医科大学附属中心医院，山东 济南 250000 |
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| 基金项目： | 山东省自然科学基金资助项目（编号:ZR2021QH034）；山东省医药卫生科技发展计划项目（编号:202009030748）；山东省济南市科技计划（编号:201907122） |
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| 摘 要： | 目的:分析胃癌组织中IL-28RA的表达情况，以及与患者临床病理特征和预后的关系。方法:对胃癌组织芯片进行IL28RA、CD8及PD-L1免疫组化染色并判读。采用χ2检验分析IL28RA蛋白表达与胃癌患者临床病理特征的关系。采用Kaplan-Meier生存分析进行预后单因素分析，使用COX回归进行多因素分析。结果:共纳入94例胃癌患者，平均年龄62.4岁，其中男性55例，病理分级1-2级患者39例，肿瘤最大直径≤5 cm的54例，83%患者肿瘤发生于胃体及胃窦(78/94),Ⅲ-Ⅳ期患者56例。我们发现癌与癌旁组织IL28RA表达无统计学差异。将IL28RA评分>3及≤3分为高表达及低表达组，结果显示IL28RA表达在肿瘤TNM分期及PD-L1表达情况存在差异(P<0.05),而与性别、年龄、肿瘤部位、大小等方面无差异。IL28RA高表达的胃癌患者预后更好(P=0.01)。多因素分析显示TNM分期、CD8+T细胞比例和IL28RA表达水平是影响胃癌预后的独立预测因素，HR分别为1.39(P=0.04)、0.55(P=0.04)和0...
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| 关 键 词： | 胃癌 IL28RA表达 生存预后 CD8+T细胞 |
The expression of IL28RA in gastric cancer tissue and its relationship with clinical pathological features and prognosis |
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| SU Chen,ZHANG Guoshan,PAN Jiachao,ZHENG Yawen. The expression of IL28RA in gastric cancer tissue and its relationship with clinical pathological features and prognosis[J]. Journal of Modern Oncology, 2023, 0(13): 2486-2490. DOI: 10.3969/j.issn.1672-4992.2023.13.021 |
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| Authors: | SU Chen ZHANG Guoshan PAN Jiachao ZHENG Yawen |
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| Affiliation: | Central Hospital Affiliated to Shandong First Medical University,Shandong Jinan 250000,China. |
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| Abstract: | Objective:To analyze the expression of IL28RA in gastric cancer tissue and its relationship with clinical pathological characteristics and prognosis of patients.Methods:Immunohistochemical staining of IL28RA,CD8 and PD-L1 was performed on gastric cancer tissue chip.χ2 test was used to analyze the relationship between IL28RA protein expression and clinicopathologic features of gastric cancer patients.Kaplan-Meier survival analysis for univariate analysis and COX regression for multivariate analysis were performed.Results:In 94 patients with gastric cancer,the average age was 62.4 years old,and the number of male patients was 55 cases,39 patients with pathological grade 1-2,54 cases with tumor diameter of 5 cm or less,56 cases with stage III-IV and 83% of patients with tumor occurred in the gastric body and antrum (78/94).There was no statistical difference in the expression of IL28RA between cancer and adjacent cancer.The patients were divided into high expression group and low expression group according to the IL28RA score >3 or ≤3.The results showed that the expression of IL28RA was different in tumor stage and PD-L1 expression (P＜0.05),but there was no difference with gender,age,tumor site and size.Gastric cancer patients with high expression of IL28RA had better prognosis (P=0.01).TNM stage,CD8+T cell proportion and IL28RA expression were independent prognostic factors of gastric cancer,and HR was 1.39 (P=0.04),0.55 (P=0.04) and 0.50 (P=0.02),respectively.Patients with low TNM staging,high percentage of CD8+T cell infiltration,and high expression of IL28RA had a better prognosis.When the three factors were combined to predict survival,the area under ROC curve reached 0.727.Conclusion:Our study showed that high expression of IL28RA in patients with gastric cancer predicted better prognosis,suggesting IL28RA as a potential prognostic factor of gastric cancer. |
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| Keywords: | gastric cancer expression of IL28RA survival CD8+T cells |
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