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| 比较基因组杂交技术:贲门癌和淋巴结转移灶的染色体变化特征 | |
| 引用本文： | 秦艳茹,王立东,邝丽芸,关新元,庄则豪. 比较基因组杂交技术:贲门癌和淋巴结转移灶的染色体变化特征[J]. 世界华人消化杂志, 2005, 13(1): 15-19 |
| 作者姓名： | 秦艳茹 王立东 邝丽芸 关新元 庄则豪 |
| 作者单位： | 1. 郑州大学一附院肿瘤科,河南省,郑州市,450052 2. 郑州大学医学院癌症研究室,河南省,郑州市,450052 3. 香港大学临床肿瘤学系 |
| 基金项目： | 国家杰出青年科学基金,No．30025016河南省医学科技创新人才工程项目,No．2003-26 |
| 摘 要： | |
| 关 键 词： | 贲门癌 比较基因组杂交 淋巴结转移 |
| 修稿时间： | 2004-09-29 |
Comparative genomic hybridization for the profile of chromosomal imbalances in cardia adenocarcinoma and metastatic lymph node lesions |
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| Yan-Ru Qin,Li-Dong Wang,Dora Kwong,Xin-Yuan Guan,Ze-Hao Zhuang. Comparative genomic hybridization for the profile of chromosomal imbalances in cardia adenocarcinoma and metastatic lymph node lesions[J]. World Chinese Journal of Digestology, 2005, 13(1): 15-19 | |
| Authors: | Yan-Ru Qin Li-Dong Wang Dora Kwong Xin-Yuan Guan Ze-Hao Zhuang |
| Affiliation: | Yan-Ru Qin,Department of Oncology,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China Li-Dong Wang,Ze-Hao Zhuang,Labortory for Cancer Research,Medical College of Zhengzhou University,Zhengzhou,450052,Henan Province,China Dora Kwong,Xin-Yuan Guan,Department of Clinical Oncology,The University of Hong Kong,Hong Kong,China |
| Abstract: | AIM: To profile the chromosomal imbalances in gastric cardia adenocarcinoma (GCA) and the metastatic lymph node (LN) lesions from the high incidence area of esoph-ageal squamous cell carcinoma/GCA in Henan province, and to provide the molecular basis for identifying the related genes for GCA and GCA lymph nodes metastasis. METHODS: Chromosomal imbalances were studied in 30 GCA resection specimens and 7 metastatic LN lesions by comparative genomic hybridization (CGH). RESULTS: In 30 GCA specimens, a total of 126 gains and 117 losses were found, and the average gain and loss was 4.2 and 3.9, respectively. The chromosomal gain most frequently identified in GCA was on 20q (43%), and others were on 6q (40%), 8q (37%), 6p (33%), 7q (33%), 1q (30%), 7p (27%), 13q (23%), 11q (20%) and 5p (20%) respectively. Losses were observed predominantly on 17p (57%), 19q (50%), 1p (47%), 3p (30%) and 4p (20%). In 7 LN lesions, a total of 75 gains and 58 losses were found, and the average gain and loss were 10.7 and 8.3, respectively. Gains were detected on chromosome 8q (5/ 7), 20 (4/7) and 1q, 2p, 3q, 6,7,11p11-q13,11q14-q23,13 (3/7 each), and deletions on chromosome 9p13-qter (4/7), 4 (3/7) and 1 pter-1q33,7p12-qter, 16p, 17p, 18 (2/7 each). CONCLUSION: The gains of 20q, 6q, 8q, 7p, 6p, 7q, 1q, 13q, 11q, 5p and losses of 17p, 19q, 1p, 3p, 4p are specifically implicated in GCA, and gains of 8q, 20q and losses of 9p, 4pq may be associated with lymph node metastasis. |
| Keywords: | CGH GCA Lymph node metastasis |
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