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| 线状硬斑病107例临床及影像学特点回顾性分析 | |
| 引用本文： | 周海燕 唐鹤菡 陈冲 吕玲 吕小岩. 线状硬斑病107例临床及影像学特点回顾性分析[J]. 中华皮肤科杂志, 2021, 54(9): 798-803. DOI: 10.35541/cjd.20201056 |
| 作者姓名： | 周海燕 唐鹤菡 陈冲 吕玲 吕小岩 |
| 作者单位： | 1四川大学华西医院皮肤科，成都610041；2四川大学华西医院放射科，成都610041第一作者现在四川大学华西公共卫生学院/华西第四医院皮肤科工作 |
| 摘 要： | 目的:分析不同亚型线状硬斑病（LM）的临床表现、实验室及影像学检查特点,对LM的诊断和病情评估方法提出建议。方法:回顾性分析2018年1月至2019年12月四川大学华西医院皮肤科门诊经临床和/或病理确诊的LM患者的临床资料。结果:共纳入107例LM患者，肢体LM 63例，刀劈状硬斑病22例，进行性颜面偏侧萎缩和嗜酸性筋... |
| 关 键 词： | 线状硬斑病 肢体线状硬斑病 刀劈状硬斑病 进行性颜面偏侧萎缩 嗜酸性筋膜炎 |
| 收稿时间： | 2020-10-30 |
Clinical and imaging characteristics of 107 patients with linear morphea: a retrospective analysis |
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| Zhou Haiyan,Tang Hehan,Chen Chong,Lyu Ling,Lyu Xiaoyan. Clinical and imaging characteristics of 107 patients with linear morphea: a retrospective analysis[J]. Chinese Journal of Dermatology, 2021, 54(9): 798-803. DOI: 10.35541/cjd.20201056 | |
| Authors: | Zhou Haiyan Tang Hehan Chen Chong Lyu Ling Lyu Xiaoyan |
| Affiliation: | 1Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China; 2Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China Zhou Haiyan is working at West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China |
| Abstract: | 【Abstract】 Objective To analyze clinical, laboratory and imaging characteristics of different subtypes of linear morphea （LM）, and to propose an appropriate approach to the diagnosis and severity assessment of LM. Methods Clinical data were collected from patients with clinically and/or pathologically confirmed LM in Department of Dermatology, West China Hospital, Sichuan University from January 2018 to December 2019, and retrospectively analyzed. Results A total of 107 patients with LM were enrolled into this study, including 63 with LM of the limbs/trunk , 22 with morphea en coup de sabre, 11 with progressive hemifacial atrophy and 11 with eosinophilic fasciitis. Disease severity was evaluated by using the modified localized scleroderma skin severity index （mLoSSI） and localized scleroderma skin damage index （LoSDI） scores in 88 patients, with the mLoSSI scores ranging from 0 to 51 points, and the LoSDI scores ranging from 0 to 40 points. Routine blood examination of 10 patients with eosinophilic fasciitis showed increased eosinophil counts in 4 patients. Thirteen （14.8%） of 88 patients with LM were positive for antinuclear antibody, with titers of ≥ 1∶320. Magnetic resonance imaging （MRI） examination showed ipsilateral cerebral hemisphere atrophy and contralateral white matter hyperintensity on T2-weighted images in 2 out of 4 patients with progressive hemifacial atrophy, myofascial thickening in 26 out of 28 patients with LM of the limbs/trunk （92.9%）, subcutaneous septal and myofascial thickening in all 11 patients with eosinophilic fasciitis. Conclusions The preliminary assessment of disease activity, severity and prognosis of LM can be made by mLoSSI and LoSDI. MRI examination is recommended for patients with clinical signs of involvement of subcutaneous structures. |
| Keywords: | Linear morphea Linear morphea of the limbs/trunk Morphea en coup de sabre Progressive hemifacial atrophy Eosinophilic fasciitis |
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