| 人参皂苷-Rg3 的药理作用研究进展 |
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| 引用本文： | 苏晓梅张丹参. 人参皂苷-Rg3 的药理作用研究进展[J]. 神经药理学报, 2017, 7(1): 38-44. DOI: 10.3969/j.issn.2095-1396.2017.01.005 |
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| 作者姓名： | 苏晓梅张丹参 |
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| 作者单位： | 河北科技大学，石家庄，050000，中国 |
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| 基金项目： | 国家自然基金项目(No.81274005)；河北省自然科学基金项目(No.H2016208058)；河北省教育厅科学技术研究重点项目(No.ZD2016009) |
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| 摘 要： | 人参是我国传统名贵中药材，药用历史悠久。人参中生理活性的最主要成分是人参皂苷，其中人参皂苷-Rg3 是一种药用价值极高的中药成分，研究其药理作用，可以为人参皂苷-Rg3 的进一步开发和利用提供理论指导。该文以近年来国内外关于人参皂苷-Rg3 的文献为基础，对其药理作用进行总结和分析。文献报道的药理研究表明，人参皂苷-Rg3 具有抗肿瘤、降低化疗药物的心脏毒性和肾毒性、翻转肿瘤细胞对抗癌药物的多药耐药性、保护中枢神经系统和心血管系统、抗疲劳、降血糖、修复创面等广泛药理作用。
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| 关 键 词： | 人参皂苷-Rg3 药理作用 抗肿瘤 中枢神经系统 心血管系统 |
Research Progress in Pharmacological Activities of Ginsenoside-Rg3 |
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| SU Xiao-mei,ZHANG Dan-shen. Research Progress in Pharmacological Activities of Ginsenoside-Rg3[J]. Journal of Hebei North University(Medical Edition), 2017, 7(1): 38-44. DOI: 10.3969/j.issn.2095-1396.2017.01.005 |
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| Authors: | SU Xiao-mei ZHANG Dan-shen |
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| Affiliation: | Hebei University of Science and Technology，Shijiazhuang，050000，China |
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| Abstract: | Ginseng is a traditional Chinese drug，with a long medicinal history. The main active components of ginseng are the ginsenosides，among which the ginsenoside-Rg3 is a kind of components in ginseng，with higher medicinal value，studying on the pharmacological effects can provide theoretical guidance for further development and utilization of ginsenoside-Rg3. According to domestic and foreign researches reports of ginsenoside-Rg3 in recent years，the pharmacological effects of ginsenoside-Rg3 were summarized and analyzed in this review. The pharmacological studies reported in the literature have indicated that the ginsenoside-Rg3 exhibited various pharmacological activities，such as anti-tumor，reduce the cardiac toxicity and nephrotoxicity of chemotherapy drugs，reverse the multidrug resistance of tumor cells to anticancer drugs，protect the central nervous system and cardiovascular system，anti-fatigue，hypoglycemic effect，repair wound，and other aspects. |
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| Keywords: | ginsenoside-Rg3 pharmacological activitiy anti-tumor central nervous system cardiovascular system |
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