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Design,synthesis and pharmacological evaluation of caffeic acid phenethyl ester acylation as multifunctional neuroprotective agents against oxidative stress injury |
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| Authors: | Renzong Zhu Xianling Ning Zhili Zhang Xiaowei Wang Chao Tian Junyi Liu |
| Abstract: | 4-Acylated or 3,4-diacylated caffeic acid phenethyl ester (CAPE) was prepared as prodrug to improve its stability and lipid solubility. Their neuroprotective activities were assessed by H2O2 model and 6-OHDA model. The results showed that target compounds displayed positive abilities to protect PC12 nerve cells from oxidative stress injury, superior to that of CAPE. Additionally, target compounds showed high blood-brain barrier permeability. |
| Keywords: | Amyotrophic lateral sclerosis Acylation Caffeic acid phenethyl ester Neuroprotective agents Blood-brain barrier permeability |
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