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CD8+ T cells are activated during the early Th1 and Th2 immune responses in a murine Lyme disease model. |
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| Authors: | Z Dong M D Edelstein L J Glickstein |
| Abstract: | T-helper responses following Borrelia burgdorferi infection in mice determine susceptibility to Lyme arthritis. The ratio of interleukin 4-positive, CD4+ to gamma interferon (IFN-gamma)-positive, CD4+ T cells was significantly greater in infected BALB/cJ mice than in infected C3H/HeJ mice. Increased numbers of IFN-gamma-producing cells predicted greater arthritis severity, and CD8+ T cells were the main source of IFN-gamma in both strains. |
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