| 肾衰养真胶囊对5/6肾切除慢性肾衰营养不良大鼠残余肾组织的影响 |
| |
| 引用本文： | 李玉明,魏连波,邓聪. 肾衰养真胶囊对5/6肾切除慢性肾衰营养不良大鼠残余肾组织的影响[J]. 南方医科大学学报, 2007, 27(6): 787-791 |
| |
| 作者姓名： | 李玉明 魏连波 邓聪 |
| |
| 作者单位： | 南方医科大学珠江医院中西结合肾病中心,广东,广州,510282 |
| |
| 基金项目： | 国家自然科学基金 , 广东省自然科学基金 |
| |
| 摘 要： | 目的 观察肾衰养真胶囊对5/6肾切除慢性肾衰竭营养不良大鼠残余肾组织的影响.方法 5/6肾切除,同时予4%酪蛋白饮食,制作慢性肾衰竭营养不良大鼠模型,称取体质量,检测血尿素氮、肌酐、白蛋白、血红蛋白及24 h尿蛋白定量等,观察营养不良出现时间,符合条件的随机分为模型组、肾衰养真胶囊治疗组、开同治疗组,另设正常对照组.灌胃4周后应用光学显微镜(包括HE、PAS染色),透射电镜以及免疫荧光观察肾组织病理学改变.结果 造模组2次术后10周末符合CRF营养不良大鼠模型条件;肾衰养真胶囊可降低血尿素氮、肌酐,减轻24 h尿蛋白定量,升高白蛋白、血红蛋白:经肾衰养真胶囊治疗的大鼠肾组织病理改变有明显改善.结论 肾衰养真胶囊可改善慢性肾衰竭营养不良大鼠营养不良,可减轻慢性肾衰竭营养不良大鼠肾损伤.
|
| 关 键 词： | 肾衰养真胶囊 慢性肾衰竭 营养不良 电镜 免疫荧光 |
| 文章编号： | 1673-4254（2007）06-0787-05 |
| 修稿时间： | 2006-11-29 |
Effect of Shenshuai Yangzhen capsule on remnant renal tissue following 5/6 nephrectomy in malnutrition rats with chronic renal failure |
| |
| LI Yu-ming,WEI Lian-bo,DENG Cong. Effect of Shenshuai Yangzhen capsule on remnant renal tissue following 5/6 nephrectomy in malnutrition rats with chronic renal failure[J]. Journal of Southern Medical University, 2007, 27(6): 787-791 |
| |
| Authors: | LI Yu-ming WEI Lian-bo DENG Cong |
| |
| Affiliation: | Department of Nephoropathy with Integrated Traditional Chinese and Western Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China |
| |
| Abstract: | Objective To investigate effects of Shenshuai Yangzhen capsule, a preparation of traditional Chinese medicine, on remnant renal tissue following nephrectomy in malnutrition rats with chronic renal failure. Methods SD rats were subjected to 5/6 nephrectomy and fed 4% casein diet to induce chronic renal failure (CRF), and their blood urea nitrogen (BUN), serum creatinine (Scr), serum albumin (ALB), hemoglobin (Hb), 24-hour urineprotein (24-h Upro) and body weight were measured. Upon the onset of malnutrition, the rats were randomized into CRF control group (CC), ketosteril group (KT), and Shenshuai Yangzhen group (SSYZ), with also a normal control group (NC). After 4 weeks of treatment as indicated, the remnant nephrotic tissue was examined under optical and electron microscopes and by immunofluorescence assay. Results Malnutrition occurred in the CRF rats at the end of the 10th weeks after the operation. Compared with those in CC group, the plasma BUN, SCr and 24-h Upro levels in SSYZ group were significantly lower with substantially elevated plasma ALB and Hb. The pathological changes of SSYZ group was significantly improved after treatment with Shenshuai Yangzhen capsule. Conlusion Shenshuai Yangzhen capsule can improve malnutrition and reduce renal damage in rats with renal insufficiency. |
| |
| Keywords: | capsule, Shenshuai Yangzhen chronic renal failure malnutrition electron microscope immunofluorescence |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《南方医科大学学报》浏览原始摘要信息 |
|
点击此处可从《南方医科大学学报》下载全文 |
|
