| 椎体注射骨水泥强化治疗骨质疏松性胸腰椎体压缩骨折 |
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| 引用本文： | 陈军平,齐新文,李松军,邝立鹏,袁小洪,王国寿,谭伟源. 椎体注射骨水泥强化治疗骨质疏松性胸腰椎体压缩骨折[J]. 中国组织工程研究, 2015, 19(21): 3292-3296. DOI: 10.3969/j.issn.2095-4344.2015.21.003 |
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| 作者姓名： | 陈军平 齐新文 李松军 邝立鹏 袁小洪 王国寿 谭伟源 |
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| 作者单位： | 遵义医学院第五附属(珠海)医院骨科，广东省珠海市 519100 |
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| 摘 要： | 背景：椎体成形注射骨水泥可在复位骨折的同时，达到矫正后凸畸形、增强椎体强度、消除椎体病变的效果。目的：分析椎体注射骨水泥强化疗法在骨质疏松性胸腰椎体压缩骨折中的应用效果。方法：选择84例骨质疏松性胸腰椎体压缩性骨折患者，病变椎体T6-L4，其中男37例，女47例，年龄58-80岁，采用随机数表法均分为2组，研究组进行椎体注射骨水泥强化治疗，对照组进行卧床休息、定期进行腰背肌功能锻炼的保守治疗。对比两组治疗前后的目测类比评分、功能障碍评分和椎体高度。结果与结论：两组治疗前的椎体高度、目测类比评分和功能障碍评分比较差异均无显著性意义；研究组治疗后3个月的椎体高度为(1.653±0.168) cm，显著高于对照组的(1.521±0.200) cm(P < 0.05)；研究组随访3个月及末次随访的目测类比评分和功能障碍评分均低于对照组(P < 0.05)。对照组治疗后，2例发生压疮，3例发生深静脉血栓，1例发生肺炎，2例发生泌尿系统感染；研究组4例发生骨水泥渗漏，但未引发明显的临床症状。对照组中有3例发生再骨折，研究组有4例发生再骨折，两组再骨折发生率比较差异无显著性意义(P > 0.05)。表明椎体注射骨水泥强化治疗骨质疏松性胸腰椎体压缩性骨折能迅速镇痛，短期内改善患者生活质量，且能较好恢复脊椎高度。
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| 关 键 词： | 生物材料 骨生物材料 椎体强化疗法 骨水泥 骨质疏松 胸腰椎体压缩骨折 |
Bone cement injection as vertebral augmentation therapy for osteoporotic vertebral compression fractures |
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| Chen Jun-ping,Qi Xin-wen,Li Song-jun,Kuang Li-peng,Yuan Xiao-hong,Wang Guo-shou,Tan Wei-yuan. Bone cement injection as vertebral augmentation therapy for osteoporotic vertebral compression fractures[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(21): 3292-3296. DOI: 10.3969/j.issn.2095-4344.2015.21.003 |
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| Authors: | Chen Jun-ping Qi Xin-wen Li Song-jun Kuang Li-peng Yuan Xiao-hong Wang Guo-shou Tan Wei-yuan |
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| Affiliation: | Department of Orthopedics, the Fifth Affiliated Hospital of Zunyi Medical College, Zhuhai 519100, Guangdong Province, China |
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| Abstract: | BACKGROUND:Vertebroplasty with bone cement injection can achieve a correction of kyphosis, enhancement of vertebral strength, and elimination of vertebral lesions during reduction of the fracture. OBJECTIVE:To analyze the efficacy of vertebroplasty with bone cement injection on osteoporotic vertebral compression fracture. METHODS:Totally 84 patients with osteoporotic thoracolumbar vertebral compression fractures (T6-L4), 37 males and 47 females, aged 58-80 years, were randomized into two groups: study group undergoing vertebroplasty with bone cement injection and control group subject to bed rest and conservative treatment (functional exercise of the back muscle). Visual analog scale score, Oswestry disability index and vertebral height were detected and compared between the two groups before and after treatment. RESULTS AND CONCLUSION:There was no difference in vertebral height, visual analog scale score and Oswestry disability index between the two groups before treatment. At 3 months after treatment, the vertebral height was (1.653±0.168) cm in the study group and (1.521±0.200) cm in the control group, with a significant difference (P < 0.05). The visual analog scale scores and Oswestry disability index scores in the study group were both lower than those in the control group at 3 months after treatment and at the last follow-up (P < 0.05). After treatment, there were two cases of pressure sores, three cases of deep venous thrombosis, one case of pneumonia and two cases of urinary tract infections in the control group; while only 4 cases developed bone cement leakage in the study group, but with no obvious clinical symptoms. No difference in re-fracture rate occurred between the control group (n=3) and study group (n=4; P > 0.05). These findings suggest that the bone cement injection as vertebral augmentation therapy can rapidly relieve pain, improve patients’ quality of life within a short term and restore the vertebral height in patients with osteoporotic vertebral compression fractures. |
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| Keywords: | Vertebroplasty,Acrylic Resins ,Osteoporotic Fractures, |
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