In Vitro Antimycobacterial Activity of 5-Chloropyrazinamide |
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| Authors: | Michael H. Cynamon Robert J. Speirs John T. Welch |
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| Affiliation: | Veterans Affairs Medical Center, Syracuse, New York 13210,1. and Department of Chemistry, SUNY at Albany, Albany, New York 122222. |
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| Abstract: | 5-Chloropyrazinamide and 5-chloropyrazinoic acid were evaluated for in vitro activity against Mycobacterium tuberculosis, Mycobacterium bovis, and several nontuberculous mycobacteria by a broth dilution method. 5-Chloropyrazinamide was more active than pyrazinamide against all organisms tested. It is likely that this agent has a different mechanism of action than pyrazinamide. |
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