| 不同剂量新斯的明拮抗国产阿曲库铵肌松效应的观察 |
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| 引用本文： | 朱凡,沈亮,傅维安. 不同剂量新斯的明拮抗国产阿曲库铵肌松效应的观察[J]. 蚌埠医学院学报, 2004, 29(1): 34-35 |
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| 作者姓名： | 朱凡 沈亮 傅维安 |
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| 作者单位： | 上海第二医科大学附属瑞金医院卢湾分院麻醉科, 200020 |
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| 摘 要： | 目的: 观察不同剂量的新斯的明拮抗国产阿曲库铵肌松效应。方法: 30例ASA Ⅰ~Ⅱ级择期手术患者分为3组,每组10例,分别给新斯的明20 μg/kg (N20)、35 μg/kg (N35)、50 μg/kg (N50)拮抗国产阿曲库铵肌松作用,并测定各组TOF0.70的时间。结果: 新斯的明20 μg/kg产生的肌松恢复弱于35 μg/kg和50 μg/kg。而35 μg/kg和50 μg/kg所产生的肌松拮抗效果相似。结论: 新斯的明剂量由20 μg/kg增加到50 μg/kg时,肌松拮抗加快,35 μg/kg为较理想剂量。
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| 关 键 词： | 新斯的明 阿曲库铵 肌松弛 拮抗剂 |
| 文章编号： | 1000-2200(2004)01-0034-02 |
| 收稿时间： | 2003-06-20 |
| 修稿时间： | 2003-06-20 |
Effect of dose of neostigmine on recovery from atracurium-induced neuromuscular blockade |
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| ZHU Fan,SHEN Liang,FU Wei an. Effect of dose of neostigmine on recovery from atracurium-induced neuromuscular blockade[J]. Journal of Bengbu Medical College, 2004, 29(1): 34-35 |
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| Authors: | ZHU Fan SHEN Liang FU Wei an |
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| Affiliation: | Department of Anesthesiology, Luwan Branch, Ruijin Hospital, Affiliated to Shanghai Second Medical University, Shanghai 200020, China |
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| Abstract: | Objective: To investigate the effect of dose of neostigmine administration on recovery from atracrium induced neuromuscular blockade.Methods: Thirty patients(ASA Ⅰ and Ⅱ) were divided into three groups(each ten),and received neostigmine 20 μg/kg,35 μg/kg and 50 μg/kg,respectively.Results: The speed of recovery from atracurium induced neuromuscular blockade with neostigmine 20 μg/kg was lower as compared with 35 μg/kg and 50 μg/kg,but the difference was not significant between with neostigmine 35 μg/kg and 50 μg/kg.Conclusions: Recovery from atracurium-induced neuromuscular blockade was accelerated when dose of neostigmine was increased from 20 μg/kg to 50 μg/kg,35 μg/kg is the optimal dose of neostigmine for reversal of atracurium induced neuromuscular blockade. |
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| Keywords: | neostigmine atracurium muscle relaxation antagonists |
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