| 血管紧张素转换酶2基因多态性与2型糖尿病合并冠心病遗传易感性的关系 |
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| 引用本文： | 严全能,徐春生,李志樑,周鹏,叶仁清,李明,姜朝新. 血管紧张素转换酶2基因多态性与2型糖尿病合并冠心病遗传易感性的关系[J]. 南方医科大学学报, 2008, 28(8): 1365-1368 |
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| 作者姓名： | 严全能 徐春生 李志樑 周鹏 叶仁清 李明 姜朝新 |
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| 作者单位： | 南方医科大学珠江医院心内科,广东,广州,510282;南方医科大学珠江医院急诊科,广东,广州,510282;南方医科大学珠江医院内分泌科,广东,广州,510282;南方医科大学珠江医院超声科,广东,广州,510282;南方医科大学珠江医院检验科,广东,广州,510282 |
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| 摘 要： | 目的 探讨血管紧张素转换酶2(ACE2)基因多态性与2型糖尿病患者及其心血管并发症的关系.方法 选择门诊与住院的汉族无血缘关系的糖尿病患者215例,分为单纯2型糖尿病组(121例)及T2DM合并冠心病组(94例).应用PCR-RFLP方法检测ACE2基因多态性,并结合临床、生化指标及超声心动图参数进行分析.结果 在2型塘尿病合并冠心病组患者中,男性G8790A位点G等位基因室间隔厚度明显高于A等位基因(P＜0.01),左心室质量指数及校正后尿蛋白量均高于A等位基因(P＜0.05).而在糖尿病组及女性糖尿病合并冠心病组中未得出同样结论.结论 ACE2基因G8790A位点多态性与男性2型糖尿病患者合并冠心病的室间隔、左室质量及尿蛋白含量有关.
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| 关 键 词： | 血管紧张素转换酶2 基因多态性 2型糖尿病 冠心病 |
Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus |
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| YAN Quan-neng,XU Chun-sheng,LI Zhi-liang,ZHOU Peng,YE Ren-qing,LI Ming,JIANG Chao-xin. Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus[J]. Journal of Southern Medical University, 2008, 28(8): 1365-1368 |
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| Authors: | YAN Quan-neng XU Chun-sheng LI Zhi-liang ZHOU Peng YE Ren-qing LI Ming JIANG Chao-xin |
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| Affiliation: | Department of Cardiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. |
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| Abstract: | OBJECTIVTo investigate the association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms and coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). METHODS: This study involved 121 patients with T2DM and 94 with diabetic macroangiopathy. The polymophisms of G8790A in ACE2 gene was analyzed using PCR-restriction fragment length polymorphism analysis in these patients, and the clinical, biochemical and echocardiographic data were also analyzed. RESULTS: No obvious difference was found in the genotyping data between the two groups. Among the male patients with diabetic macroangiopathy, the interventricular septal end-diastolic thickness (IVSTd) were significantly greater in patients of GG genotypes of ACE2 gene G8790A than in those of AA genotypes (P<0.01), and the left ventricular mass (LVMI) and urine protein were also significantly higher in GG genotypes (P<0.05). No similar results were found the uncomplicated diabetic group or the female diabetic patients with CAD. CONCLUSION: The ACE2 gene G8790A polymorphism plays a role in the pathogenesis of CAD in patients with type 2 diabetes, suggesting that ACE2 genotyping is helpful to screen the susceptible patients. |
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| Keywords: | angiotensin converting enzyme 2 polymorphism type 2 diabetes mellitus coronary heart disease |
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