| 新型七甲川菁染料用作肿瘤模型活体成像的研究进展 |
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| 引用本文： | 王哲轩,赵宁宁,张彩勤,李卓昊,师长宏. 新型七甲川菁染料用作肿瘤模型活体成像的研究进展[J]. 实验动物与比较医学, 2016, 24(1): 97-101 |
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| 作者姓名： | 王哲轩 赵宁宁 张彩勤 李卓昊 师长宏 |
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| 作者单位： | 第四军医大学实验动物中心,第四军医大学实验动物中心,第四军医大学实验动物中心,第四军医大学实验动物中心,第四军医大学实验动物中心 |
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| 基金项目： | 国家自然科学基金（编号：31572340）军队实验动物专项课题 （编号：SYDW2014-002） |
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| 摘 要： | 一种近红外荧光（NIRF）七甲川菁染料不需要化学修饰，可直接被肿瘤细胞吸收呈特异性聚集，从而可用于肿瘤活体成像。这种染料在肿瘤细胞与正常细胞之间的摄取差异可能是由于特异型有机阴离子转运肽的作用，并受到低氧条件控制。这些特性将会拓展NIRF类染料在肿瘤成像研究中的应用。
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| 关 键 词： | 近红外荧光；七甲川菁染料； 肿瘤靶向性；活体成像；有机阴离子转运肽 |
| 收稿时间： | 2015-08-19 |
| 修稿时间： | 2015-09-09 |
Advances in research of novel heptamethine cyanine dyes as a potential diagnostic agent for optical imaging of tumor models |
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| WANG Zhe-xuan,ZHAO Ning-ning,ZHANG Cai-qin,LI Zhuo-hao and SHI Chang-hong. Advances in research of novel heptamethine cyanine dyes as a potential diagnostic agent for optical imaging of tumor models[J]. Laboratory Animal and Comparative Medicine, 2016, 24(1): 97-101 |
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| Authors: | WANG Zhe-xuan ZHAO Ning-ning ZHANG Cai-qin LI Zhuo-hao SHI Chang-hong |
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| Affiliation: | Student Brigade of the Forth Battalion, 15th Company, The Fourth Military Medical University, Xi''an 710032, China;Laboratory Animal Center, The Fourth Military Medical University, Xi''an 710032, China;Laboratory Animal Center, The Fourth Military Medical University, Xi''an 710032, China;Laboratory Animal Center, The Fourth Military Medical University, Xi''an 710032, China;Student Brigade of the Forth Battalion, 15th Company, The Fourth Military Medical University, Xi''an 710032, China;Laboratory Animal Center, The Fourth Military Medical University, Xi''an 710032, China |
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| Abstract: | A class of near infrared fluorescence (NIRF) heptamethine cyanine dyes, in their native form without chemical conjugation, can be taken up and accumulated specifically in the cancer cells and used for tumors imaging. The different uptake of the dyes into cancer but not normal cells is possible due to the presence of specific isoforms of organic anion-transporting peptides (OATPs), and regulated by hypoxia. These advances have widely extended current application of cancer diagnosis by NIRF imaging. |
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| Keywords: | near infrared fluorescence heptamethine cyanine dyes tumor target optical imaging organic anion-transporting peptides (OATPs) |
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