| 慢性淋巴细胞白血病合并急性髓系白血病多学科协作诊疗1例 |
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| 引用本文： | 宁乔杨,杨洪亮,夏冰,白丽萍,曹增,王慧君,张翼鷟,尤明健. 慢性淋巴细胞白血病合并急性髓系白血病多学科协作诊疗1例[J]. 中国肿瘤临床, 2017, 44(7): 337-343. DOI: 10.3969/j.issn.1000-8179.2017.07.464 |
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| 作者姓名： | 宁乔杨 杨洪亮 夏冰 白丽萍 曹增 王慧君 张翼鷟 尤明健 |
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| 作者单位： | ①.天津医科大学肿瘤医院血液科，国家肿瘤临床医学研究中心，天津市肿瘤防治重点实验室，天津市恶性肿瘤临床医学研究中心（天津市300060） |
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| 基金项目： | 本文课题受国家自然科学基金项目(81270603)，美国M.D.安德森肿瘤中心姊妹医院合作项目资助 This work was supported by grants from the National Natural Science Foundation of China(81270603)，Sister Institution Net-work Fund (SINF) University of Texas MD Anderson Cancer Center |
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| 摘 要： | 天津医科大学肿瘤医院血液科2014年6月收治慢性淋巴细胞白血病（chronic lymphocytic leukemia，CLL）患者1例，该患者第1个周期化疗1个月后，在原有CLL细胞亚群的基础上发现另一群急性髓系白血病（acute myeloid leukemia，AML）细胞亚群。此后，虽然未经针对性治疗，但肿瘤在较长时间内（约11个月余）均呈现稳定状态。通过回顾患者前期的相关检查，明确此病例为极其罕见的CLL/AML。汇集综合血液科、分子诊断科、病理科等多学科的诊疗意见和延伸讨论，本研究通过此病例对CLL/AML、肿瘤二次打击学说与肿瘤树状演化模型有了比较全面和直观的认识。
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| 关 键 词： | 慢性淋巴细胞白血病 急性髓系白血病 多学科协作 |
| 收稿时间： | 2016-12-25 |
Multidisciplinary team confirmed the simultaneous diagnosis of CLL and AML-M5 |
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| Qiaoyang NING,Hongliang YANG,Bing XIA,Liping BAI,Zeng CAO,Huijun WANG,Yizhuo ZHANG,Mingjian YOU. Multidisciplinary team confirmed the simultaneous diagnosis of CLL and AML-M5[J]. Chinese Journal of Clinical Oncology, 2017, 44(7): 337-343. DOI: 10.3969/j.issn.1000-8179.2017.07.464 |
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| Authors: | Qiaoyang NING Hongliang YANG Bing XIA Liping BAI Zeng CAO Huijun WANG Yizhuo ZHANG Mingjian YOU |
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| Abstract: | A 54-year-old man diagnosed with chronic lymphocytic leukemia (CLL) was admitted in our department in June 2014. After one cycle of FC chemotherapy, a bone marrow examination revealed normalized lymphocyte count and another acute myeloid leuke-mia (AML)-M5 clone. The patient refused sequential treatment and only received follow-up examination. He had continuous hemato-logically stable disease and died of pulmonary infection on July 2015. After a multidisciplinary team discussion, we confirmed the si-multaneous diagnosis of CLL and AML-M5. Through this discussion,"tumor second hit model,""tumor evolution model,"and"tumor heterogeneity"were further defined. |
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| Keywords: | chronic lymphocytic leukemia acute myeloid leukemia multidisciplinary team |
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