| 微管相关蛋白2在胰腺神经内分泌肿瘤组织中的表达及预后意义 |
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| 引用本文： | 宋甜甜,肖雨,白春梅,李乃适,陈洁,赵大春,宋玉立,金凯舟,朱丽明,于润,虞先濬,陈原稼. 微管相关蛋白2在胰腺神经内分泌肿瘤组织中的表达及预后意义[J]. 中国肿瘤临床, 2017, 44(11): 532-538. DOI: 10.3969/j.issn.1000-8179.2017.11.190 |
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| 作者姓名： | 宋甜甜 肖雨 白春梅 李乃适 陈洁 赵大春 宋玉立 金凯舟 朱丽明 于润 虞先濬 陈原稼 |
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| 作者单位： | ①.中国医学科学院，北京协和医学院，北京协和医院消化内科（北京市100730） |
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| 基金项目： | the National Natural Sciences Foundation of China (No. 81450015)本文课题受国家自然科学基金应急管理项目(81450015) |
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| 摘 要： | 目的 探索微管相关蛋白2（microtubule-associated protein 2，MAP2）与微管相关蛋白1B（microtubule-associated protein 1B，MAP1B）在预测胰腺神经内分泌肿瘤（pancreatic neuroendocrine tumors，PNETs）患者预后中的意义。 方法 收集1999年12月至2016年12月来自于北京协和医院、中山大学附属第一医院、复旦大学上海癌症中心和Cedars-Sinai医学中心（洛杉矶）193例患者的193个原发肿瘤标本。免疫组织化学染色法分别检测193例、120例PNETs组织中MAP2、MAP1B的表达，随后分析蛋白表达与患者临床病理特征及预后的关系。 结果 MAP2和MAP1B在PNETs患者中的阳性率分别为45.6%（88/193）和64.2%（77/120）。MAP2表达阳性的患者的总生存好于阴性患者（P=0.012）。另外，MAP2阳性Ⅱ、Ⅲ期患者的总生存也优于阴性者（P=0.017）。然而，MAP1B的表达与肿瘤大小、转移、肿瘤组织学分级、临床分期、总生存、无病生存均无相关性（P > 0.05）。 结论 MAP2为潜在的预测PNETs患者预后的指标。
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| 关 键 词： | 微管相关蛋白2 胰腺神经内分泌肿瘤 预后 |
| 收稿时间： | 2017-02-01 |
Expression of microtubule-associated protein 2 correlates with better prognosis of pancreatic neuroendocrine tumors |
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| Tiantian SONG,Yu XIAO,Chunmei BAI,Naishi LI,Jie CHEN,Dachun ZHAO,Yuli SONG,Kaizhou JIN,Liming ZHU,Run YU,Xianjun YU,Yuanjia CHEN. Expression of microtubule-associated protein 2 correlates with better prognosis of pancreatic neuroendocrine tumors[J]. Chinese Journal of Clinical Oncology, 2017, 44(11): 532-538. DOI: 10.3969/j.issn.1000-8179.2017.11.190 |
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| Authors: | Tiantian SONG Yu XIAO Chunmei BAI Naishi LI Jie CHEN Dachun ZHAO Yuli SONG Kaizhou JIN Liming ZHU Run YU Xianjun YU Yuanjia CHEN |
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| Abstract: | Objective: To determine whether microtubule-associated protein 2 (MAP2) and microtubule-associated protein 1B (MAP1B) could be prognostic biomarkers for patients with pancreatic neuroendocrine tumors (PNETs). Methods:With immunohisto-chemical staining, the expressions of MAP2 and MAP1B were examined in 193 and 120 primary tumors and peritumoral tissues, re-spectively. Then, the relationship between the expression of each protein and clinicopathological characteristics, including prognosis was analyzed. Results:MAP2 and MAP1B were expressed in 88 of 193 (45.6%) and 77 of 120 (64.2%) tumors, respectively. The expres-sion of MAP2 was significantly associated with the favorable overall survival of patients with PNETs (P=0.012). Moreover, MAP2 expres-sion was associated with the improved overall survival in a subset of patients with stageⅡand stageⅢtumors (P=0.017). The MAP1B expression did not correlate with other clinicopathological features and prognosis. Conclusion:MAP2 could be a novel, independent prognostcbiomarker for PNETs. |
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| Keywords: | microtubule-associated protein 2 pancreatic neuroendocrine tumors prognosis |
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