| 双表型肝细胞癌新亚型的临床病理学研究进展 |
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| 引用本文： | 王瀚,丛文铭. 双表型肝细胞癌新亚型的临床病理学研究进展[J]. 中国肿瘤临床, 2017, 44(12): 616-619. DOI: 10.3969/j.issn.1000-8179.2017.12.071 |
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| 作者姓名： | 王瀚 丛文铭 |
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| 作者单位： | 第二军医大学东方肝胆外科医院病理科，教育部重点实验室（肝癌分子网络调控与靶向干预），上海市肝胆肿瘤生物学重点实验室（第二军医大学东方肝胆外科医院）（上海市200438） |
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| 基金项目： | the National Natural Science Foundation of China(81472278)，Funds for Creative Research Groups of National Natural Science Foundation of China (No. 81521091)本文课题受国家自然科学基金(81472278)，国家自然科学基金委创新群体基金(81521091) |
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| 摘 要： | 双表型肝细胞癌（dual-phenotype hepatocellular carcinoma，DPHCC）是近年报道的肝细胞癌（hepatocellular carcinoma，HCC）的一种新亚型，以组织学上为典型的肝细胞癌但同时表达肝细胞癌和肝内胆管癌（intrahepatic cholangiocarcinoma，ICC）的基因标志物为特征，因其具有HCC和ICC的双重生物学行为，恶性程度更高，临床预后差，因而正确诊断十分重要。CK19是DPHCC诊断的重要标志物之一，可以通过多种途径参与DPHCC的发生和恶性生物学行为的调控。本文拟从DPHCC的临床病理特点、免疫组织化学标记、组织起源发生等方面对DPHCC的研究进展进行综述。
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| 关 键 词： | 双表型肝细胞癌 诊断 CK19 组织发生 肿瘤异质性 |
| 收稿时间： | 2017-01-18 |
Research progress on clinicopathology in dual-phenotype hepatocellular carcinoma |
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| Affiliation: | Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University; Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Second Military Medical University, Ministry of Education; Shanghai Key Laboratory of Hepatobiliary Tumor Biology, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China |
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| Abstract: | Dual-phenotype hepatocellular carcinoma (DPHCC) is a novel subtype of hepatocellular carcinoma (HCC). DPHCC presents the classical morphology of HCC but simultaneously expresses the biomarkers of HCC and intrahepatic cholangiocarcinoma (ICC). Accu-rate diagnosis of DPHCC is necessary because of its combined biological behaviors of HCC and ICC, highly malignant degree, and in-faust clinical prognosis. CK19 is an important marker of DPHCC and regulates the clonal origin and biological behavior of DPHCC in vari-ous pathways. In this paper, we reviewed the research progress of DPHCC focusing mainly on its clinicopathological features, immuno-histochemical biomarkers, and histogenesis. |
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| Keywords: | DPHCC diagnosis CK19 histogenesis tumor heterogeneity |
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