| 肝硬化患者血清胰岛素样生长因子-1的变化及其临床意义 |
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| 引用本文： | HU Ying,徐雯. 肝硬化患者血清胰岛素样生长因子-1的变化及其临床意义[J]. 实用医学杂志, 2008, 24(14): 2416-2418 |
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| 作者姓名： | HU Ying 徐雯 |
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| 作者单位： | 上海交通大学医学院附属新华医院消化内科,200092 |
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| 摘 要： | 目的：研究肝硬化患者血清胰岛素样生长因子-1（IGF-1）的变化及其临床意义。方法：肝硬化患者79例，根据Child-Pugh评分分为3组，A级组21例。B级组29例。C级组29例，另选取20例正常体检者为正常组。Child-PughA、B、C级肝硬化患者再根据其入院症状分为消化道出血组与非出血组。ELISA法测定血清IGF-1值．全自动生化分析仪常规方法测定肝脏生化指标。结果：肝硬化A、B、C级组患者血清IGF-1水平与正常组比较均明显降低（P〈0.01）；肝硬化A、B、C级组间比较IGF-1水平亦有明显差异（P〈0.01或P〈0．05）；Child-PughA、B、C级肝硬化患者消化道出血组院者与非出血组IGF-1值无明显差异（P〉0.05）。结论：肝硬化患者IGF-1水平明显下降，而且其下降程度与肝脏病变程度有关；IGF-1可作为肝硬化患者肝脏功能及预后的评价指标。但是不能作为预测上消化道出血概率的指标
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| 关 键 词： | 肝硬化 胃肠出血 胰岛素样生长因子Ⅰ |
| 收稿时间： | 2008-01-30 |
Clinical significance of serum insulin-like growth fuctor-1(IGF-1)in liver cirrhosis |
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| HU Ying,XU Wen. Clinical significance of serum insulin-like growth fuctor-1(IGF-1)in liver cirrhosis[J]. The Journal of Practical Medicine, 2008, 24(14): 2416-2418 |
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| Authors: | HU Ying XU Wen |
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| Affiliation: | HU Ying,XU Wen. Department of Gastroenterology,Xinhua Hospital,Shanghai Jiaotong University,Shanghai 200092,China |
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| Abstract: | Objective To investigate the clinical significance of serum insulin-like growth fuctor-1(IGF-1) in patients with liver cirrhosis. Methods 79 patients with liver cirrhosis were divided into 3 groups according to severity of cirrhosis (Child-Pugh score) and 20 healthy subjects served as controls. Patients in each serious group of cirrhosis were divided into 2 groups according to whether they got a gastrointestinal hemorrhage or not. Serum IGF-1 levels were measured by enzyme-linked immunosorbent assay (ELISA). Results Serum IGF-1 levels were significantly lower in patients with cirrhosis than in controls(P < 0.01), and serum concentrations of IGF-1 were associated with the severity of cirrhosis. Serum IGF-1 levels in patients with gastrointestinal hemorrhage had no difference from those without gastrointestinal hemorrhage(P > 0.05). Conclusion Serum IGF-1 levels are associated with the severity of liver dysfunction, and dropped sharply during the progression of liver dysfunction. It is a good potential index to value the severity of liver cirrhosis, but has no value to be used to estimate gastrointestinal hemorrhage risk. |
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