Prognostic Value of NRAS Gene for Survival of Colorectal Cancer Patients: A Systematic Review and Meta-Analysis |
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| Authors: | Yue Hu1Shuang-You Tao2Jie-Min Deng1Zheng-Kun Hou3Jia-Qi Liang1Qiu-Gu Huang4Liang-Hui Li1Hui-Biao Li3Yi-Ming Chen1Hua Yi1Xin-lin Chen1Hui Liu4 |
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| Affiliation: | 1School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou, China.2Spleen and Stomach Institute, Guangzhou University of Chinese Medicine, Guangzhou, China.3The First Affiliated Hospital,Guangzhou University of Chinese Medicine, Guangzhou, China.4The Third Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China. |
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| Abstract: | Introduction: NRAS gene is associated with malignant proliferation and metastasis of colorectal cancer (CRC).But its prognostic value on CRC is still unknown. The objective of this study is to perform a meta-analysis to obtainits prognostic value on survival of CRC patients. Methods: The systematic review and meta-analysis was designed,undertaken and reported using items from the PRISMA statement. Relevant articles were identified through PubMed(containing Medline), Embase, Web of Science databases and Google scholar search engines from their inception up toOctober 3, 2016. The articles about NRAS on prognosis of CRC patients were enrolled. The association between NRASand CRC survival time (including overall survival [OS], progression-free survival [PFS], and disease-free survival[DFS]) was evaluated using hazard ratio (HR) with its corresponding 95% confidence interval (CI). Results: A totalof fifteen articles were included. High-expression of NRAS was significantly associated with poor OS (HR: 1.36, 95%CI: 1.15–1.61), and poor PFS (HR: 1.75, 95% CI: 1.04–2.94). The combined HR of NRAS on DFS was 0.87 (95% CI:0.37–2.03). Subgroup analysis showed that NRAS was significantly associated with poor OS for patients from Westerncountries (HR: 1.38, 95% CI: 1.09–1.73), but not for those from Asian countries. Conclusions: This meta-analysisdemonstrate that NRAS gene could predict the poor prognosis for the CRC patients. More large-sample cohort studiesare needed to further confirm this conclusion. |
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| Keywords: | NRAS gene colorectal cancer Prognosis Meta-analysis |
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