| 2型糖尿病患者大脑静息葡萄糖代谢改变研究 |
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| 引用本文： | 马藤,轩昂,张杰,付畅,孙萌萌,尤阳,徐俊玲. 2型糖尿病患者大脑静息葡萄糖代谢改变研究[J]. 国际放射医学核医学杂志, 2018, 42(1): 25-29. DOI: 10.3760/cma.j.issn.1673-4114.2018.01.005 |
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| 作者姓名： | 马藤 轩昂 张杰 付畅 孙萌萌 尤阳 徐俊玲 |
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| 作者单位： | 450000, 郑州大学人民医院PET/CT中心 |
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| 基金项目： | 河南省医学科技攻关计划省部共建项目201701026 |
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| 摘 要： | 目的探讨静息状态下2型糖尿病（T2DM）患者大脑葡萄糖代谢改变特点。方法回顾性分析96例已被临床确诊的T2DM患者的头部18F-FDG PET/CT显像资料。选取96名健康体检者作为对照组。采用统计参数地形图 8软件分析T2DM患者组与对照组PET脑代谢的改变。T2DM患者组与对照组图像采用体素对体素的两独立样本t检验。结果与对照组比较，T2DM患者18F-FDG PET/CT表现为多个脑区的葡萄糖代谢减低（t=5.51~6.42，均P < 0.001），主要包括双侧额中下回、双侧颞上横回、双侧枕上中舌回、双侧楔前叶、双侧顶下缘角回、距状裂及周围皮层；未见明显代谢增高脑区。结论T2DM患者大脑静息葡萄糖代谢改变以区域性葡萄糖代谢减低为主，且基本呈双侧对称分布，主要涉及的脑区包括情感、认知功能区和视觉皮层区等。
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| 关 键 词： | 糖尿病 2型 脑葡萄糖代谢 氟脱氧葡萄糖F18 正电子发射断层显像术 体层摄影术 X线计算机 统计参数地形图 |
| 收稿时间： | 2017-09-08 |
Changes in resting-state brain glucose metabolism in patients with type 2 diabetes |
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| Teng Ma,Ang Xuan,Jie Zhang,Chang Fu,Mengmeng Sun,Yang You,Junling Xu. Changes in resting-state brain glucose metabolism in patients with type 2 diabetes[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2018, 42(1): 25-29. DOI: 10.3760/cma.j.issn.1673-4114.2018.01.005 |
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| Authors: | Teng Ma Ang Xuan Jie Zhang Chang Fu Mengmeng Sun Yang You Junling Xu |
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| Affiliation: | PET/CT Center, the People's Hospital of Zhengzhou University, Zhengzhou 450000, China |
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| Abstract: | ObjectiveTo invetigate the metabolic changes in the resting brain glucose of patients with type 2 diabetes but without brain metastasis.MethodsA total of 96 patients with type 2 diabetes were confirmed by 18F-FDG PET/CT examination. The whole-body 18F-FDG PET/CT images of the patients were retrospectively analyzed. Ninety-six healthy subjects were included as controls for comparison. The metabolic changes in resting brain glucose of the 96 patients with type 2 diabetes were analyzed using a statistical parametric mapping software. Data were processed with two independent sample t test of voxel to voxel in the images.ResultsCompared with the control group, the hypometabolic brain areas in patients with type 2 diabetes were in the bilateral middle-inferior frontal, bilateral superior-heschl gyrus, bilateral superior-middle-lingual gyrus, calcarine cortex, bilateral inferior parietal gyrus, and bilateral wedge anterior lobe(t=5.51-6.42, all P < 0.001). Hypermetabolic areas were not observed in patients.ConclusionsThe reduced metabolic cerebral regions in the patients with type 2 diabetes involved a number of functional regions related to visual cortex and mood disorders. |
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| Keywords: | Diabetes mellitus, type 2 Brain glucose metabolism Fluorodeoxyglucose F18 Positron-emission tomography Tomography, X-ray computed Statistical parametric mapping |
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