Ki-67 Prognostic Value in Different Histological Grades of Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma |
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| Authors: | Amer Takkem1Charif Barakat1Safa Zakarea1Khaled Zaid1Johnny Najmeh2Mahdi Ayoub3Mohammad Yaman Seirawan4 |
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| Affiliation: | 1Department of Oral Histology and Pathology, University of Damascus,Damascus, Syria.2Department of Periodontology, University of Damascus,Damascus, Syria.3DESS Dental Public Health, Lebanese University, Beirut , Lebanon.4Department of Endodontics and Operative Dentistry, Faculty of Dentistry, University of Damascus, Damascus, Syria. |
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| Abstract: | Introduction: Abnormal cell proliferation appears to be a possible predictor of tumorigenesis, Ki-67 proteinexpression is closely related to the cell proliferation and could be used as a biomarker for the growth in the most ofhuman tumors. The aim of the study: Investigating of Ki-67 expression in the pathological grades of oral epithelialdysplasia and oral squamous cell carcinomas. Materials and Methods: The sample consisted of 30 formalin-fixed,paraffin-embedded specimens of oral epithelial dysplasia (OED), 30 other of oral squamous cell carcinomas (OSCC), and10 normal oral epithelium (NOE) were conventionally stained with hematoxylin and eosin and immunohistochemicallystained with Ki-67 monoclonal antibody. Results: Expression of Ki-67 was restricted to the basal layers in the normaloral epithelium whereas Ki-67 positive cells in oral epithelial dysplasia (OED) were located in the basal, suprabasaland spinous layers, Ki-67 expression was increased in high-risk cases. Ki-67 positive cells in well-differentiated(OSCC) were located mainly in the periphery of the tumor nests, in moderately-differentiated (OSCC) were locatedin both peripheral and part of a center of the tumor nests whereas it was diffused in most of the Poorly-differentiated(OSCC). Statistical analysis indicated a significant difference between the expression in (OED) and (NOE), (OSCC)and (NOE), and no differences between (OED) and (OSCC). Conclusion: This study has concluded that Ki-67 antigencould be used as a marker for the histological grading of OED and OSCC, Expression of Ki 67 increased according tothe severity of oral epithelial dysplasia. |
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| Keywords: | Ki-67 antigen Oral epithelial dysplasia (OED) Oral squamous cell carcinomas (OSCC) Normal oral epithelium (NOE) |
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